Die Another Day: A Painless Path to Longevity

被引：5

作者：

Steculorum, Sophie M. ^{[1
,2
,3
,4
]}

Bruening, Jens C. ^{[1
,2
,3
,4
]}

机构：

[1] Max Planck Inst Neurol Res, D-50931 Cologne, Germany

[2] Univ Cologne, Univ Hosp Cologne, Ctr Endocrinol Diabet & Prevent Med CEDP, Inst Genet,Dept Mouse Genet & Metab, D-50674 Cologne, Germany

[3] CMMC, D-50674 Cologne, Germany

[4] Cologne Excellence Cluster Cellular Stress Respo, D-50674 Cologne, Germany

来源：

CELL | 2014年 / 157卷 / 05期

关键词：

LIFE-SPAN; RECEPTOR; MICE; NEURONS;

D O I：

10.1016/j.cell.2014.05.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Riera et al. identify a neuroendocrine circuit that controls longevity and the age-dependent onset of metabolic decline via the pain-transducing channel TRPV1. Thus, pharmacological inhibition of TRPV1 may provide a new approach to treat not only metabolic disorders but also a broader range of age-related pathologies.

引用

页码：1004 / 1006

页数：3

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