Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft

被引：6
作者：
Setoguchi, Kiyoshi [1 ,2 ,7 ,8 ]
Kawashima, Yoichiro [3 ,9 ]
Tokumoto, Tadahiko [1 ,4 ,7 ,10 ]
Toma, Hiroshi [1 ,7 ]
Mizoguchi, Shogo [1 ,7 ]
Horita, Shigeru [5 ,11 ]
Yamaguchi, Yutaka [6 ,12 ]
Tanabe, Kazunari [5 ,11 ]
机构：
[1] Toda chuo Gen Hosp, Dept Transplant Surg & Urol, Saitama, Japan
[2] Saiseikai Kurihashi Hosp, Dept Urol, Saitama, Japan
[3] Dept Nephrol, Saijin Clin, Saitama, Japan
[4] Shonan Kamakura Gen Hosp, Dept Transplant Surg & Urol, Kanagawa, Japan
[5] Tokyo Womens Med Univ, Dept Urol, Tokyo, Japan
[6] Yamaguchis Pathol Lab, Chiba, Japan
[7] Toda Chuo Gen Hosp, Dept Transplant Surg & Urol, Saitama, Japan
[8] Saiseikai Kurihashi Hosp, Dept Urol, Saitama, Japan
[9] Saijin Clin, Dept Nephrol, Saitama, Japan
[10] Shonan Kamakura Gen Hosp, Dept Transplant Surg & Urol, Kamakura, Kanagawa, Japan
[11] Tokyo Womens Med Univ, Dept Urol, Tokyo, Japan
[12] Yamaguchis Pathol Lab, Chiba, Japan
来源：
NEPHROLOGY | 2014年 / 19卷
关键词：
glomerulonephritis; immunoglobulin A; kidney transplantation; membranoproliferative; rituximab; IGG DEPOSITS; NEPHROPATHY; RITUXIMAB; KIDNEY; RECURS;
D O I：
10.1111/nep.12251
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We herein describe the unique case of a 59-year-old man who underwent living kidney transplantation for IgA nephropathy (IgAN) and developed progressive kidney failure associated with the appearance of proliferative glomerulonephritis. An early protocol biopsy revealed recurrent IgAN with mesangial IgA2 deposits restricted to a single immunoglobulin light-chain isotype. Despite treatment with tonsillectomy and rituximab, the patient eventually lost his allograft 31 months after transplantation. Serum electrophoresis showed a monoclonal IgA pattern. This case might share common pathological characteristics with the newly described entity referred to as proliferative glomerulonephritis with monoclonal IgG deposits.
引用
收藏
页码：49 / 51
页数：3
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