Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram-Positive Pathogens

被引：6

作者：

Viault, Guillaume ^{[1
]}

Kempf, Marie ^{[2
,3
]}

Ville, Alexia ^{[1
]}

Alsabil, Khaled ^{[1
]}

Perrot, Rodolphe ^{[4
]}

Richomme, Pascal ^{[1
]}

Helesbeux, Jean-Jacques ^{[1
]}

Seraphin, Denis ^{[1
]}

机构：

[1] Univ Angers, SFR QUASAV, Fac Hlth Sci, 16 Bd Daviers, F-49045 Angers 01, France

[2] CHU Angers, Dept Biol Agents Infect, 4 Rue Larrey, F-49933 Angers 01, France

[3] CHU Angers, Inst Natl Sante & Rech Med INSERM, 4 Rue Larrey, F-49933 Angers 01, France

[4] CHU Angers, Serv Commun Imageries & Anal Microscop SCIAM, 4 Rue Larrey, F-49933 Angers 01, France

来源：

CHEMMEDCHEM | 2021年 / 16卷 / 05期

关键词：

antibacterial agents; vitamin E; methicillin-resistant Staphylococcus aureus; natural products; semisynthesis; NATURAL-PRODUCTS; ACID; ANTIBIOTICS; METHICILLIN;

D O I：

10.1002/cmdc.202000792

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New 5-substituted vitamin E derivatives were semisynthesized, and their antibacterial activity against human Gram-positive and Gram-negative pathogens was evaluated. Several vitamin E analogues were active against methicillin-resistant Staphylococcus aureus (MRSA) and/or methicillin-resistant Staphylococcus epidermidis (MRSE); structure-activity relationships (SARs) are discussed. As a result, it is shown that the presence of a carboxylic acid function at the C-5 position and/or at the end of the side chain is crucial for the antibacterial activity. The bactericidal or bacteriostatic action of three compounds against MRSA and MRSE was confirmed in a time-kill kinetics study, and the cytotoxicity on human cells was evaluated. The preliminary mechanism study by confocal microscopy indicated that those vitamin E analogues led to bacterial cell death through membrane disruption.

引用

页码：881 / 890

页数：10

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