PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients

被引:22
作者
Bailly, Clement [1 ,2 ]
Leforestier, Rodolphe [2 ]
Jamet, Bastien [2 ]
Carlier, Thomas [1 ,2 ]
Bourgeois, Mickael [1 ,2 ]
Guerard, Francois [1 ]
Touzeau, Cyrille [2 ]
Moreau, Philippe [2 ]
Cherel, Michel [1 ,3 ]
Kraeber-Bodere, Francoise [1 ,2 ,3 ]
Bodet-Milin, Caroline [1 ,2 ]
机构
[1] Univ Nantes, Nantes Angers Canc Res Ctr CRCNA, INSERM, UMR 1232, 8 Quai Moncousu, F-44007 Nantes, France
[2] CHU Nantes, Dept Nucl Med, 1 Pl Alexis Ricordeau, F-44093 Nantes, France
[3] ICO Rene Gauducheau, Dept Nucl Med, Blvd Jacques Monod, F-44805 St Herblain, France
关键词
multiple myeloma; solitary plasmacytoma; PET; CT; therapeutic evaluation; POSITRON-EMISSION-TOMOGRAPHY; F-18-FDG PET/CT; FDG-PET/CT; CRITERIA; LESIONS; PROGRESSION; PREDICTION; EXPERIENCE; DIAGNOSIS; MRI;
D O I
10.3390/ijms18020445
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multiple myeloma (MM) is a hematological neoplasm characterized by the clonal proliferation of malignant plasma cells in the bone marrow. MM results in diffuse or focal bone infiltration and extramedullary lesions. Over the past two decades, advances have been made with regard to the diagnosis, staging, treatment, and imaging of MM. Computed tomography (CT) and magnetic resonance imaging (MRI) are currently recommended as the most effective imaging modalities at diagnostic. Yet, recent data from the literature suggest that positron emission tomography combined with computed tomography (PET/CT) using F-18-deoxyglucose (FDG) is a promising technique for initial staging and therapeutic monitoring in this pathology. This paper reviews the recent advances as well as the potential place of a more specific radiopharmaceutical in MM.
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页数:8
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