Design, synthesis, and evaluation of novel 1-methyl-3-substituted quinazoline-2,4-dione derivatives as antimicrobial agents

被引：11

作者：

Ji, Qing-Gang ^{[1
]}

Yang, Dan ^{[1
]}

Deng, Qiao ^{[1
]}

Ge, Zhi-Qiang ^{[1
]}

Yuan, Lv-Jiang ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 05期

关键词：

Quinazoline-2,4-dione; Amide; Antibacterial; Antifungal agents; ANTIBACTERIAL AGENTS; RESISTANCE; DRUGS; IV;

D O I：

10.1007/s00044-013-0813-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 1-methyl-3-substituted quinazoline-2,4-dione derivatives was designed, synthesized, and evaluated for their antimicrobial activities against six strains of bacteria and five fungi in vitro. The synthesized compounds were characterized by spectral methods. The bioactive assays showed that most of the compounds exhibited moderate antimicrobial activities against the tested strains.

引用

页码：2169 / 2177

页数：9

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