HP1 and the dynamics of heterochromatin maintenance

被引：481
作者：
Maison, C [1 ]
Almouzni, G [1 ]
机构：
[1] Inst Curie, Sect Rech, CNRS, Unite MIxte Rech 218, F-75231 Paris 05, France
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 04期
基金：
欧盟地平线“2020”;
关键词：
D O I：
10.1038/nrm1355
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure the proper segregation of chromosomes and the regulation of gene expression. Although it is architecturally stable, heterochromatin has to be flexible to cope with disrupting events such as replication. Recent progress has shed light on the paradoxical properties of heterochromatin in the nucleus, and highlights the roles of heterochromatin protein-1 and, more unexpectedly, RNA molecules in heterochromatin maintenance.
引用
收藏
页码：296 / 304
页数：9
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