The unconventional expression of IL-15 and its role in NK cell homeostasis

被引：87
作者：
Huntington, Nicholas D. [1 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2014年 / 92卷 / 03期
基金：
英国医学研究理事会;
关键词：
gamma chain cytokines; innate immunity; NK cells; NATURAL-KILLER-CELLS; TRANS-PRESENTATION; CUTTING EDGE; DENDRITIC CELLS; SOLUBLE INTERLEUKIN-15R-ALPHA; DEVELOPMENTAL PATHWAYS; MICE LACKING; BONE-MARROW; BETA-CHAIN; RECEPTOR;
D O I：
10.1038/icb.2014.1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effector role in the clearance of virus-infected and transformed cells. NK cells are dependent on the pleiotropic cytokine interleukin (IL)-15 for their development, differentiation and optimal function. Here I review the regulation of IL-15 in vivo, its role in driving NK cell differentiation and discuss the function of NK cell diversification with regard to innate immunity.
引用
收藏
页码：210 / 213
页数：4
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