Homeotic Transformations of Neuronal Cell Identities

被引：35

作者：

Arlotta, Paola ^{[1
]}

Hobert, Oliver ^{[2
,3
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[2] Columbia Univ, Howard Hughes Med Inst, Dept Biol, New York, NY 10032 USA

[3] Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

TRENDS IN NEUROSCIENCES | 2015年 / 38卷 / 12期

基金：

美国国家卫生研究院;

关键词：

CORTICOFUGAL NEURONS; SELECTOR GENE; HOX GENES; FATE; SPECIFICATION; DIFFERENTIATION; DIVERSITY; CONNECTIVITY; REPRESSION; EXPRESSION;

D O I：

10.1016/j.tins.2015.10.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homeosis is classically defined as the transformation of one body part into something that resembles another body part. We propose here to broaden the concept of homeosis to the many neuronal cell identity transformations that have been uncovered over the past few years upon removal of specific regulatory factors in organisms from Caenorhabditis elegans to Drosophila, zebrafish, and mice. The concept of homeosis provides a framework for the evolution of cell type diversity in the brain.

引用

页码：751 / 762

页数：12

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