Using immunoproteomics to identify tumor-associated antigens (TAAs) as biomarkers in cancer immunodiagnosis

被引：44

作者：

Zhu, Qing ^{[1
,2
]}

Liu, Mei ^{[2
,3
]}

Dai, Liping ^{[2
,4
,5
]}

Ying, Xia ^{[1
]}

Ye, Hua ^{[2
,4
,5
]}

Zhou, Yusen ^{[6
]}

Han, Suxia ^{[1
]}

Zhang, Jian-Ying ^{[2
,4
,5
]}

机构：

[1] Xi An Jiao Tong Univ, Med Ctr, Affiliated Hosp 1, Dept Med Oncol, Xian 710049, Shaanxi, Peoples R China

[2] Univ Texas El Paso, Dept Biol Sci, El Paso, TX 79968 USA

[3] Capital Med Univ, Beijing YouAn Hosp, Beijing, Peoples R China

[4] Zhengzhou Univ, Henan Key Lab Tumor Epidemiol, Zhengzhou 450052, Henan, Peoples R China

[5] Zhengzhou Univ, Prote Res Ctr, Zhengzhou 450052, Henan, Peoples R China

[6] Beijing Inst Microbiol & Epidemiol, Dept Pathogen Mol Biol, Beijing, Peoples R China

来源：

AUTOIMMUNITY REVIEWS | 2013年 / 12卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Autoantibody; Tumor-associated antigen; Immunoproteomics; Immunodiagnosis; Cancer; HUMORAL IMMUNE-RESPONSE; CHRONIC LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; NUCLEAR AUTOANTIGEN; PROTEOMIC APPROACH; ANTIBODY DETECTION; PROSTATE-CANCER; S-PHASE; AUTOANTIBODIES; PROTEIN;

D O I：

10.1016/j.autrev.2013.06.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since intracellular proteins involved in carcinogenesis have been shown to provoke autoantibody responses, autoantibodies can be used as probes in immunoproteomics to isolate, identify, and characterize potential tumor-associated antigens (TAAs). Once a TAA is identified, several approaches will be used to comprehensively characterize and validate the identified TAA/anti-TAA systems that are potential biomarkers in certain types of cancer. Our ultimate goal is to establish rigorous criteria for designation of an autoantibody to a TAA as a cancer biomarker, examine candidate TAAs for sensitivity and specificity of anti-TAA antibody response, and further develop customized TAA arrays that can be used to enhance anti-TAA antibody detection in cancer. This review will mainly focus on the recent advances in our studies using immunoproteomic approach to identify and characterize TAAs as biomarkers in cancer. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1123 / 1128

页数：6