Analysis of the reactions used for the preparation of drug candidate molecules

被引：1687

作者：

Carey, John S. ^{[1
]}

Laffan, David

Thomson, Colin

Williams, Mike T.

机构：

[1] GlaxoSmithKline, Old Powder Mills, Tonbridge, England

[2] AstraZeneca PR&D, Macclesfield SK10 2NA, Cheshire, England

[3] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

[4] Pfizer Ltd, Global R&D, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 12期

关键词：

D O I：

10.1039/b602413k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R& D departments of GlaxoSmithKline, AstraZeneca and Pfizer.

引用

页码：2337 / 2347

页数：11

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