Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives

被引：46

作者：

Khalilullah, Habibullah ^{[1
,2
]}

Khan, Shamshir ^{[4
]}

Nomani, Md. Shivli ^{[3
]}

Ahmed, Bahar ^{[2
]}

机构：

[1] Alwar Pharm Coll, Dept Pharmaceut Chem, Alwar 301030, Rajasthan, India

[2] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

[3] Alwar Pharm Coll, Dept Pharmaceut Microbiol & Biotechnol, Alwar 301030, Rajasthan, India

[4] Qassim Univ, Fac Pharm, Dept Pharmaceut Chem, Buraydah, Saudi Arabia

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2016年 / 9卷

关键词：

1,4-Benzodioxane; 1,3,4-Oxadiazole; Antibacterial; Antifungal; AGENTS;

D O I：

10.1016/j.arabjc.2011.11.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 1,3,4-oxadizole derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis and antifungal activity against Aspergillus niger, Aspergillus flavus and Candida albicans by twofold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs norfloxacin, chloramphenicol and fluconazole, against tested strains. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S1029 / S1035

页数：7

共 22 条

[1] Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents [J].

Aboraia, AS ;

Abdel-Rahman, HM ;

Mahfouz, NM ;

El-Gendy, MA .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (04) :1236-1246

[2] Reaction between N-Isocyaniminotriphenylphosphorane, Aldehydes, and Carboxylic Acids: A One-Pot and Three-Component Synthesis of 2-Aryl-5-hydroxyalkyl-1,3,4-oxadiazoles [J].

Adib, Mehdi ;

Kesheh, Mahdi Riazati ;

Ansari, Samira ;

Bijanzadeh, Hamid Reza .

SYNLETT, 2009, (10) :1575-1578

[3]

Ahmed B, 2003, PHARMAZIE, V58, P173

[4] Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives [J].

Amir, M ;

Shikha, K .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (06) :535-545

[5] ALPHA-ADRENORECEPTOR REAGENTS .1. SYNTHESIS OF SOME 1,4-BENZODIOXANS AS SELECTIVE PRE-SYNAPTIC ALPHA-2-ADRENORECEPTOR ANTAGONISTS AND POTENTIAL ANTI-DEPRESSANTS [J].

CHAPLEO, CB ;

MYERS, PL ;

BUTLER, RCM ;

DOXEY, JC ;

ROACH, AG ;

SMITH, CFC .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :823-831

[6] Synthesis, antifungal activity and CoMFA analysis of novel l,2,4-triazolo[1,5-a]pyrimidine derivatives [J].

Chen, Qiong ;

Zhu, Xiao-Lei ;

Jiang, Li-Li ;

Liu, Zu-Ming ;

Yang, Guang-Fu .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (03) :595-603

[7] Synthesis of some new substituted 2-mercaptoquinazoline analogs as potential antimicrobial agents [J].

El-Azab, Adel S. .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (02) :333-348

[8] Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid [J].

Gilani, Sadaf J. ;

Khan, Suroor A. ;

Siddiqui, Nadeem .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (16) :4762-4765

[9] Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers [J].

Guven, Ozden Ozel ;

Erdogan, Taner ;

Goker, Hakan ;

Yildiz, Sulhiye .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (08) :2233-2236

[10] Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives [J].

Jha, Keshari Kishore ;

Samad, Abdul ;

Kumar, Yatendra ;

Shaharyar, Mohd. ;

Khosa, Ratan Lal ;

Jain, Jainendra ;

Kumar, Vikash ;

Singh, Priyanka .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) :4963-4967

← 1 2 3 →