Stromal lenticule transplantation for management of corneal perforations; one year results

To study application of stromal lenticules extracted by femtolaser small incision lenticule extraction (SMILE) surgery as a surgical adjuvant to seal corneal perforations. Corneal stromal lenticules obtained through SMILE surgery with central thickness 100 mu m or more were fixed over corneal perforation sites using 10-0 nylon interrupted stitches with an overlying single layer of amniotic membrane. Seven patients who had been followed up for a minimum of 12 months were assessed using slit-lamp biomicroscopy, fluorescein stain, tonometry, and best spectacle-corrected visual acuity (BSCVA) measurements. Postoperative complications were recorded throughout the follow up period. Corneal perforations had successfully been sealed in all 7 patients; 3 patients (42.9%) exhibited improved postoperative BSCVA. During the follow-up period of one year, no signs of re-perforation or infections were detected in any patient. These early findings suggest that the use of corneal stromal lenticules could be a safe and efficient surgical adjuvant for corneal perforation closure with potential clinical application, together with amniotic membrane, as relatively simple and low cost temporary measures to prepare perforated corneas for further definitive procedures.