The Interleukin-1 Family

被引：126

作者：

Yazdi, Amir S. ^{[1
]}

Ghoreschi, Kamran ^{[1
]}

机构：

[1] Univ Tubingen, Dept Dermatol, Liebermeisterstr 25, D-72076 Tubingen, Germany

来源：

REGULATION OF CYTOKINE GENE EXPRESSION IN IMMUNITY AND DISEASES | 2016年 / 941卷

关键词：

Inflammasomes; Caspases; Autoinflammation; Nod-like receptor; IL-18; IL-33; IL-36; CELLS IN-VIVO; NALP3; INFLAMMASOME; NLRP3; INSULIN-RESISTANCE; CYTOKINE IL-33; ACTIVATION; RECEPTOR; SECRETION; ANTAGONIST; EXPRESSION;

D O I：

10.1007/978-94-024-0921-5_2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The interieukin4 (IL-1.) family consists of several pro- or antiinflammatory proteins, with pro-inflammatory IL-1 beta being its best characterized member. IL-1 beta is one of the most prominent mediators of intlanunation resulting in fever and immune activation via binding to IL-1 receptor 1. Due to its potency, its secretion is tightly regulated. First the transcription of uhe biologically inactive proform is induced by TLR activation, TNF, or IL-1 receptor activation by mature IL-1 alpha or For the secretion of IL-1 beta, inflammasome activation as second stimulus is needed. Inflammasomes are cytosolic protein complexes whose activation results in the maturation of inflammatory caspases such as caspase-1. Caspase-1. then cleaves the inactive pro-IL-1 beta into its mature form which is then being secreted. While IL-1 alpha and m-1 beta are considered pro-inflammatory, IL-1Ra as a naturally occurring receptor antagonist acts as an inhibitor on IL-1 receptor signaling. Further members of the IL-1 family, such as IL-18, IL-33, or IL-36, are even involved in T-helper-cell differentiation and will also be discussed in this chapter.

引用

页码：21 / 29

页数：9

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