Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols To Access Propargylic Stereocenters

被引：57

作者：

Chen, Zhi-Min ^{[1
]}

Nervig, Christine S. ^{[1
]}

DeLuca, Ryan J. ^{[1
]}

Sigman, Matthew S. ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, 315 South 1400 East, Salt Lake City, UT 84112 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 23期

基金：

美国国家卫生研究院;

关键词：

alkenes; alkynylation; Heck reaction; propargylic stereocenter; ASYMMETRIC CONJUGATE ALKYNYLATION; TERMINAL ALKYNES; ALLYLIC ALCOHOLS; ARYLATION; ALKENYLATION; HETEROCYCLES; ALDEHYDES; STRATEGY; HALIDES; KETONES;

D O I：

10.1002/anie.201703089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective redox-relay Heck alkynylation of di- and trisubstituted alkenols to construct propargylic stereocenters is disclosed using a new pyridine oxazoline ligand. This strategy allows direct access to chiral beta-alkynyl carbonyl compounds employing allylic alcohol substrates in contrast to more traditional conjugate addition methods.

引用

页码：6651 / 6654

页数：4

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