A microfluidic device for shape measurement in red blood cells (RBCs)

被引：0
作者：
Mencattini, Arianna [1 ]
Di Giuseppe, Davide [1 ]
D'Orazio, Michele [1 ]
Rizzuto, Valeria [2 ]
Manu Pereira, M. M. [3 ]
Colomba Comes, Maria [1 ]
Jose Lopez-Martinez, Maria [4 ,5 ]
Samitier, Josep [4 ,5 ]
Martinelli, Eugenio [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Elect Engn, Rome, Italy
[2] Inst Bioengn Catalonia IBEC, Barcelona, Spain
[3] Vall dHebron Res Inst, Barcelona, Spain
[4] Univ Barcelona, Inst Bioengn Catalonia IBEC, Barcelona, Spain
[5] Ctr Networked Biomed Res CIBER BBN, Madrid, Spain
来源：
2020 IEEE INTERNATIONAL SYMPOSIUM ON MEDICAL MEASUREMENTS AND APPLICATIONS (MEMEA) | 2020年
关键词：
time-lapse microscopy; cell tracking; plasticity measurement; anaemia diagnosis;
D O I：
10.1109/memea49120.2020.9137212
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Modern optical sensors coupled with time-lapse microscopy devices and dedicated software tools allow the miniaturization of laboratories for biological experiments leading to the Organ-On-Chip (OoC) framework. OoCs allow performing massive measurements on a large number of cells under the assumption of reproducibility conditions, permitting to investigate the cell dynamics in terms of motility and shape changes over time. In this work, we present the OoC platform used in a preliminary study of the Rare Haemolytic Anaemia (RHA) disease, a group of rare diseases characterized by haemolysis, which is the premature loss of red blood cells (RBCs). Preliminary results demonstrate the effectiveness of shape measurement for the diagnosis of RHA.
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页数：5
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