Spinal intramedullary H3K27M mutant glioma with vertebral metastasis: a case report

被引：9

作者：

Handis, Chafik ^{[1
]}

Tanrikulu, Bahattin ^{[1
]}

Danyeli, Ayca Ersen ^{[2
]}

Ozek, M. Memet ^{[1
]}

机构：

[1] Acibadem Univ, Div Pediat Neurosurg, Dept Neurosurg, Sch Med, Istanbul, Turkey

[2] Acibadem Univ, Dept Pathol, Sch Med, Istanbul, Turkey

来源：

CHILDS NERVOUS SYSTEM | 2021年 / 37卷 / 12期

关键词：

High-grade glioma; Vertebral metastasis; Midline glioma;

D O I：

10.1007/s00381-021-05119-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A new entity of gliomas, named "diffuse midline glioma (DMG), H3K27M mutant (grade IV)," which represents a specific molecular profile, was introduced to the World Health Organization (WHO) classification 2016 of central nervous system tumors. Many midline localizations have been described for this glioma, and mainly the hypothalamus, pons, thalamus, and spinal cord are sites of predilection in pediatric and young adult patients. We report the case of spinal intramedullary DMG, H3K27M mutant (WHO grade IV), that showed an unusual presentation with multiple vertebral metastases.

引用

页码：3933 / 3937

页数：5

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