Using the Key Characteristics of Carcinogens to Develop Research on Chemical Mixtures and Cancer

被引：24

作者：

Rider, Cynthia, V ^{[1
]}

McHale, Cliona M. ^{[2
]}

Webster, Thomas F. ^{[3
]}

Lowe, Leroy ^{[4
]}

Goodson, William H., III ^{[5
]}

La Merrill, Michele A. ^{[6
]}

Rice, Glenn ^{[7
]}

Zeise, Lauren ^{[8
]}

Zhang, Luoping ^{[2
]}

Smith, Martyn T. ^{[2
]}

机构：

[1] NIEHS, Div Natl Toxicol Program, POB 12233,Mail Drop K2-12, Res Triangle Pk, NC 27709 USA

[2] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[3] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA

[4] Getting Know Canc NGO, Truro, NS, Canada

[5] Calif Pacific Med Ctr Res Inst, Dept Surg, San Francisco, CA USA

[6] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA

[7] US EPA, Off Res & Dev, Ctr Publ Hlth & Environm Assessment, Cincinnati, OH 45268 USA

[8] Calif Environm Protect Agcy, Off Environm Hlth & Hazard Assessment, Sacramento, CA USA

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2021年 / 129卷 / 03期

基金：

美国国家卫生研究院;

关键词：

IMMUNOSUPPRESSIVE DRUGS; ENVIRONMENTAL MIXTURES; ANIMAL-MODELS; RISK; EXPOSURE; HEALTH; MICE; MECHANISMS; HALLMARKS; PERTURBATIONS;

D O I：

10.1289/EHP8525

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

BACKGROUND: People are exposed to numerous chemicals throughout their lifetimes. Many of these chemicals display one or more of the key characteristics of carcinogens or interact with processes described in the hallmarks of cancer. Therefore, evaluating the effects of chemical mixtures on cancer development is an important pursuit. Challenges involved in designing research studies to evaluate the joint action of chemicals on cancer risk include the time taken to perform the experiments because of the long latency and choosing an appropriate experimental design. OBJECTIVES: The objectives of this work are to present the case for developing a research program on mixtures of environmental chemicals and cancer risk and describe recommended approaches. METHODS: A working group comprising the coauthors focused attention on the design of mixtures studies to inform cancer risk assessment as part of a larger effort to refine the key characteristics of carcinogens and explore their application. Working group members reviewed the key characteristics of carcinogens, hallmarks of cancer, and mixtures research for other disease end points. The group discussed options for developing tractable projects to evaluate the joint effects of environmental chemicals on cancer development. RESULTS AND DISCUSSION: Three approaches for developing a research program to evaluate the effects of mixtures on cancer development were proposed: a chemical screening approach, a transgenic model-based approach, and a disease-centered approach. Advantages and disadvantages of each are discussed.

引用

页数：11

共 101 条

[31] Modeling Physiological Events in 2D vs. 3D Cell Culture [J].

Duval, Kayla ;

Grover, Hannah ;

Han, Li-Hsin ;

Mou, Yongchao ;

Pegoraro, Adrian F. ;

Fredberg, Jeffery ;

Chen, Zi .

PHYSIOLOGY, 2017, 32 (04) :266-277

[32] Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment [J].

El Hajj, Nady ;

Schneider, Eberhard ;

Lehnen, Harald ;

Haaf, Thomas .

REPRODUCTION, 2014, 148 (06) :R111-R120

[33]

Gennings C., 2018, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk, P291

[34] Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis [J].

Gongora, Victoria Martinez ;

Matthes, Katarina L. ;

Castano, Patricia Rodriguez ;

Linseisen, Jakob ;

Rohrmann, Sabine .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2019, 28 (01) :99-109

[35] Testing the low dose mixtures hypothesis from the Halifax project [J].

Goodson, William H. ;

Lowe, Leroy ;

Gilbertson, Michael ;

Carpenter, David O. .

REVIEWS ON ENVIRONMENTAL HEALTH, 2020, 35 (04) :333-357

[36] Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead [J].

Goodson, William H., III ;

Lowe, Leroy ;

Carpenter, David O. ;

Gilbertson, Michael ;

Ali, Abdul Manaf ;

de Cerain Salsamendi, Adela Lopez ;

Lasfar, Ahmed ;

Carnero, Amancio ;

Azqueta, Amaya ;

Amedei, Amedeo ;

Charles, Amelia K. ;

Collins, Andrew R. ;

Ward, Andrew ;

Salzberg, Anna C. ;

Colacci, Annamaria ;

Olsen, Ann-Karin ;

Berg, Arthur ;

Barclay, Barry J. ;

Zhou, Binhua P. ;

Blanco-Aparicio, Carmen ;

Baglole, Carolyn J. ;

Dong, Chenfang ;

Mondello, Chiara ;

Hsu, Chia-Wen ;

Naus, Christian C. ;

Yedjou, Clement ;

Curran, Colleen S. ;

Laird, Dale W. ;

Koch, Daniel C. ;

Carlin, Danielle J. ;

Felsher, Dean W. ;

Roy, Debasish ;

Brown, Dustin G. ;

Ratovitski, Edward ;

Ryan, Elizabeth P. ;

Corsini, Emanuela ;

Rojas, Emilio ;

Moon, Eun-Yi ;

Laconi, Ezio ;

Marongiu, Fabio ;

Al-Mulla, Fahd ;

Chiaradonna, Ferdinando ;

Darroudi, Firouz ;

Martin, Francis L. ;

Van Schooten, Frederik J. ;

Goldberg, Gary S. ;

Wagemaker, Gerard ;

Nangami, Gladys ;

Calaf, Gloria M. ;

Williams, Graeme .

CARCINOGENESIS, 2015, 36 :S254-S296

[37] Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives [J].

Grandjean, Philippe ;

Barouki, Robert ;

Bellinger, David C. ;

Casteleyn, Ludwine ;

Chadwick, Lisa H. ;

Cordier, Sylvaine ;

Etzel, Ruth A. ;

Gray, Kimberly A. ;

Ha, Eun-Hee ;

Junien, Claudine ;

Karagas, Margaret ;

Kawamoto, Toshihiro ;

Lawrence, B. Paige ;

Perera, Frederica P. ;

Prins, Gail S. ;

Puga, Alvaro ;

Rosenfeld, Cheryl S. ;

Sherr, David H. ;

Sly, Peter D. ;

Suk, William ;

Sun, Qi ;

Toppari, Jorma ;

van den Hazel, Peter ;

Walker, Cheryl L. ;

Heindel, Jerrold J. .

ENDOCRINOLOGY, 2015, 156 (10) :3408-3415

[38] High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells [J].

Griner, Lesley A. Mathews ;

Guha, Rajarshi ;

Shinn, Paul ;

Young, Ryan M. ;

Keller, Jonathan M. ;

Liu, Dongbo ;

Goldlust, Ian S. ;

Yasgar, Adam ;

McKnight, Crystal ;

Boxer, Matthew B. ;

Duveau, Damien Y. ;

Jiang, Jian-Kang ;

Michael, Sam ;

Mierzwa, Tim ;

Huang, Wenwei ;

Walsh, Martin J. ;

Mott, Bryan T. ;

Patela, Paresma ;

Leister, William ;

Maloney, David J. ;

Leclair, Christopher A. ;

Rai, Ganesha ;

Jadhav, Ajit ;

Peyser, Brian D. ;

Austin, Christopher P. ;

Martin, Scott E. ;

Simeonov, Anton ;

Ferrer, Marc ;

Staudt, Louis M. ;

Thomas, Craig J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (06) :2349-2354

[39] Application of the key characteristics of carcinogens in cancer hazard identification [J].

Guyton, Kathryn Z. ;

Rusyn, Ivan ;

Chiu, Weihsueh A. ;

Corpet, Denis E. ;

van den Berg, Martin ;

Ross, Matthew K. ;

Christiani, David C. ;

Beland, Frederick A. ;

Smith, Martyn T. .

CARCINOGENESIS, 2018, 39 (04) :614-622

[40] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

← 1 2 3 4 5 6 7 8 9 10 →