Electrospun chitosan/PVA/bioglass Nanofibrous membrane with spatially designed structure for accelerating chronic wound healing
被引:115
作者:
Chen, Qingchang
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机构:
Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Chen, Qingchang
[1
]
Wu, Jun
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机构:
Univ Hong Kong Shenzhen Hosp, Shenzhen Key Lab Innovat Technol Orthopaed Trauma, Shenzhen, Peoples R China
Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulum, 21 Sassoon Rd, Hong Kong 999077, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Wu, Jun
[2
,3
]
Liu, Yuan
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机构:
Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Liu, Yuan
[1
]
Li, Yanqun
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Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Li, Yanqun
[1
]
Zhang, Chuqiu
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机构:
Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Zhang, Chuqiu
[1
]
Qi, Weichen
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机构:
Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulum, 21 Sassoon Rd, Hong Kong 999077, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Qi, Weichen
[1
,3
]
Yeung, Kelvin W. K.
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h-index: 0
机构:
Univ Hong Kong Shenzhen Hosp, Shenzhen Key Lab Innovat Technol Orthopaed Trauma, Shenzhen, Peoples R China
Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulum, 21 Sassoon Rd, Hong Kong 999077, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Yeung, Kelvin W. K.
[2
,3
]
Wong, Tak Man
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h-index: 0
机构:
Univ Hong Kong Shenzhen Hosp, Shenzhen Key Lab Innovat Technol Orthopaed Trauma, Shenzhen, Peoples R China
Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulum, 21 Sassoon Rd, Hong Kong 999077, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Wong, Tak Man
[2
,3
]
Zhao, Xiaoli
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机构:
Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Zhao, Xiaoli
[1
]
Pan, Haobo
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h-index: 0
机构:
Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R ChinaChinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
Pan, Haobo
[1
]
机构:
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
[2] Univ Hong Kong Shenzhen Hosp, Shenzhen Key Lab Innovat Technol Orthopaed Trauma, Shenzhen, Peoples R China
[3] Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulum, 21 Sassoon Rd, Hong Kong 999077, Peoples R China
来源:
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
|
2019年
/
105卷
Cutaneous wounds, especially chronic wounds, remain clinical challenges, and this is partially due to the complex healing process composed of four overlapping but distinct stages including hemostasis, inflammation, proliferation and remodeling. Therefore, wound dressings with spatially designed structures which can temporally regulate certain bioactive components to function at specific healing stages might be able to accelerate the healing process. In this study, nanobioglass incorporated chitosan-PVA (polyvinyl alcohol) trilayer nanofibrous membrane (nBG-TFM) was fabricated via sequential electrospinning. This membrane exhibited excellent biocompatibility, antibacterial activity and regeneration promotion effect. Furthermore, spatially designed structure optimized functions of each component and provided more suitable microenvironment as compared with uniform membrane. Rat full-thickness skin defects model and mice diabetic chronic wound model showed that nBG-TFM could achieve significantly accelerated and enhanced healing, in terms of complete re-epithelialization, improved collagen alignment and formation of skin appendages. It was revealed that nBG-TFM functioned through upregulating growth factors including VEGF and TGF-beta. Meanwhile inflammatory cytokines such as TNF-alpha and IL-1 beta were downregulated. The technology presented in this study shed new light on designing functional wound dressings which can promote healing of chronic wounds.
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机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Univ Rochester, Sch Med & Dent, Rochester, NY USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Barrientos, Stephan
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Stojadinovic, Olivera
论文数: 0引用数: 0
h-index: 0
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Cornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Stojadinovic, Olivera
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Golinko, Michael S.
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h-index: 0
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Columbia Univ, Coll Phys & Surg, Wound Healing Lab, New York, NY USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Golinko, Michael S.
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Brem, Harold
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Wound Healing Lab, New York, NY USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Brem, Harold
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Tomic-Canic, Marjana
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Dermatol, New York, NY 10021 USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
机构:
Univ Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Chan, Leslie W.
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Kim, Chae Hwa
论文数: 0引用数: 0
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Korea Inst Ind Technol KITECH, Tech Text & Mat Grp, Ansan 15588, South KoreaUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Kim, Chae Hwa
;
Wang, Xu
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Univ Washington, Div Emergency Med, Dept Med, Seattle, WA 98104 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Wang, Xu
;
Pun, Suzie H.
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Univ Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Pun, Suzie H.
;
White, Nathan J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Div Emergency Med, Dept Med, Seattle, WA 98104 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
White, Nathan J.
;
Kim, Tae Hee
论文数: 0引用数: 0
h-index: 0
机构:
Korea Inst Ind Technol KITECH, Tech Text & Mat Grp, Ansan 15588, South KoreaUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Univ Rochester, Sch Med & Dent, Rochester, NY USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Barrientos, Stephan
;
Stojadinovic, Olivera
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Stojadinovic, Olivera
;
Golinko, Michael S.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Wound Healing Lab, New York, NY USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Golinko, Michael S.
;
Brem, Harold
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Wound Healing Lab, New York, NY USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Brem, Harold
;
Tomic-Canic, Marjana
论文数: 0引用数: 0
h-index: 0
机构:
Cornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
Cornell Univ, Weill Med Coll, Dept Dermatol, New York, NY 10021 USACornell Univ, Hosp Special Surg, Weill Med Coll,Tissue Engn Regenerat & Repair Pro, Tissue Repair Lab, New York, NY 10021 USA
机构:
Univ Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Chan, Leslie W.
;
Kim, Chae Hwa
论文数: 0引用数: 0
h-index: 0
机构:
Korea Inst Ind Technol KITECH, Tech Text & Mat Grp, Ansan 15588, South KoreaUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Kim, Chae Hwa
;
Wang, Xu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Div Emergency Med, Dept Med, Seattle, WA 98104 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Wang, Xu
;
Pun, Suzie H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
Pun, Suzie H.
;
White, Nathan J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Div Emergency Med, Dept Med, Seattle, WA 98104 USAUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA
White, Nathan J.
;
Kim, Tae Hee
论文数: 0引用数: 0
h-index: 0
机构:
Korea Inst Ind Technol KITECH, Tech Text & Mat Grp, Ansan 15588, South KoreaUniv Washington, Dept Bioengn & Mol Engn & Sci Inst, Seattle, WA 98195 USA