Porous TiNbZr alloy scaffolds for biomedical applications

被引：158
作者：
Wang, Xiaojian [1 ]
Li, Yuncang [1 ]
Xiong, Jianyu [1 ]
Hodgson, Peter D. [1 ]
Wen, Cui'e [1 ]
机构：
[1] Deakin Univ, Inst Technol Res & Innovat, Geelong, Vic 3217, Australia
来源：
ACTA BIOMATERIALIA | 2009年 / 5卷 / 09期
基金：
澳大利亚研究理事会;
关键词：
Titanium alloy; Scaffold; Mechanical properties; Biocompatibility; BONE-GRAFT SUBSTITUTES; MECHANICAL-PROPERTIES; ELASTIC PROPERTIES; TITANIUM-ALLOYS; POROSITY; TI6AL4V; DEFORMATION; IMPLANTS; INGROWTH; FOAM;
D O I：
10.1016/j.actbio.2009.06.002
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In the present study, porous Ti-10Nb-10Zr alloy scaffolds with different porosities were successfully fabricated by a "space-holder" sintering method. By the addition of biocompatible alloying elements the porous TiNbZr scaffolds achieved significantly higher strength than unalloyed Ti scaffolds of the same porosity. In particular, the porous TiNbZr alloy with 59% porosity exhibited an elastic modulus and plateau stress of 5.6 GPa and 137 MPa, respectively. The porous alloys exhibited excellent ductility during compression tests and the deformation mechanism is mainly governed by bending and buckling of the struts. Cell cultures revealed that SaOS2 osteobldst-like cells grew on the surface and inside the pores and showed good spreading. Cell viability for the porous scaffold was three times higher than the solid counterpart. The present study has demonstrated that the porous TiNbZr alloy scaffolds are promising scaffold biomaterials for bone tissue engineering by virtue of their appropriate mechanical properties, highly porous structure and excellent biocompatibility. Crown Copyright (C) 2009 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.
引用
收藏
页码：3616 / 3624
页数：9
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