Glut-1 glucose transporter expression in esophageal squamous cell carcinoma is associated with tumor aggressiveness

被引:0
作者
Kato, H [1 ]
Takita, J [1 ]
Miyazaki, T [1 ]
Nakajima, M [1 ]
Fukai, Y [1 ]
Masuda, N [1 ]
Fukuchi, M [1 ]
Manda, R [1 ]
Ojima, H [1 ]
Tsukada, K [1 ]
Kuwano, H [1 ]
机构
[1] Gunma Univ, Fac Med, Dept Surg 1, Maebashi, Gumma 3718511, Japan
关键词
glucose transporter-1; esophageal carcinoma; immunohistochemistry; prognostic value;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Glucose transporter (Glut) proteins, which are membrane proteins responsible for the transport of glucose across cellular membranes, have six forms. To further elucidate the role of Glut-1 expression in esophageal squamous cell carcinoma, we examined the expression of Glut-1 protein immunohistochemically. Materials and Methods: Immunohistochemical expression of Glut-1 was examined in surgically resected tissues from 95 patients with esophageal squamous cell carcinoma. Results: Of the 95 esophageal carcinomas, 91 (95.8%) had some Glut-1 immunostaining in the membranes of the cancer cells. Positive staining (> 30% of cancer cells showing Glut-1 expression) was observed in 49 (51.6%) of the cases. Comparison of Glut-1 expression and clinicopathological characteristics in the 95 patients with esophageal cancer revealed significant associations between Glut-1 expression and tumor status (p < 0.001), lymph node status (p < 0.05), metastatic status (p < 0.01), and pathological stage (p < 0.001). The survival rates of patients with Glut-1-positive tumors were significantly lower than those of patients with Glut-1-negative tumors (log-rank p<0.05). Conclusion: In conclusion, the level of Glut-l expression may be a useful marker that can provide information on tumor aggressiveness and prognosis in patients with esophageal squamous cell carcinoma.
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页码:2635 / 2639
页数:5
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