Straightforward synthesis of novel spiroether derivatives

被引：13

作者：

Bobrovskaya, Olga V. ^{[1
]}

Russkih, Aleksandr A. ^{[1
]}

Yankin, Andrei N. ^{[2
]}

Dmitriev, Maksim V. ^{[3
]}

Bunev, Aleksandr S. ^{[4
]}

Gein, Vladimir L. ^{[1
]}

机构：

[1] Perm State Pharmaceut Acad, Perm, Russia

[2] ITMO Univ, Dept Phys & Engn, St Petersburg, Russia

[3] Perm State Natl Res Univ, Dept Chem, Perm, Russia

[4] Togliatti State Univ, Medicinal Chem Ctr, Tolyatti, Russia

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 11期

关键词：

Alloxan; cytotoxity; heterocycles; pyrimidine; spiroethers;

D O I：

10.1080/00397911.2021.1903930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the first full synthesis of novel spiroether derivatives via reaction of 4-oxobut-2-enoates and alloxan. Our synthesis features the single-step assembly, mild reaction conditions, good yields, high diastereoselectivity, operational simplicity, and the absence of tedious separation procedures. Most of the prepared compounds possessed moderate growth inhibitory effects on human alveolar adenocarcinoma (A549), malignant melanoma (A375), ovarian adenocarcinoma (SK-OV-3), and fibrosarcoma (HT-1080) cell lines.

引用

页码：1731 / 1741

页数：11

共 29 条

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