The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017

被引：157

作者：

Force, Lisa M. ^{[1
,2
]}

Abdollahpour, Ibrahim ^{[4
,7
]}

Advani, Shailesh M. ^{[8
,10
]}

Agius, Dominic ^{[11
]}

Ahmadian, Elham ^{[12
,14
]}

Alahdab, Fares ^{[15
]}

Alam, Tahiya ^{[16
]}

Alebel, Animut ^{[22
]}

Alipour, Vahid ^{[23
]}

Allen, Christine A. ^{[16
]}

Almasi-Hashiani, Amir ^{[4
]}

Alvarez, Elysia M. ^{[30
]}

Amini, Saeed ^{[5
]}

Amoako, Yaw Ampem ^{[31
]}

Anber, Nahla Hamed ^{[32
]}

Arabloo, Jalal ^{[23
]}

Artaman, Al ^{[33
]}

Atique, Suleman ^{[35
,36
]}

Awasthi, Ashish ^{[37
,38
]}

Bagherzadeh, Mojtaba ^{[39
]}

Basaleem, Huda ^{[40
]}

Bekru, Eyasu Tamru ^{[41
]}

Bijani, Ali ^{[42
]}

Bogale, Kassawmar Angaw ^{[109
]}

Car, Mate

Carvalho, Felix ^{[50
,51
,54
]}

Castro, Clara ^{[55
,56
]}

Catala-Lopez, Ferran ^{[58
,59
]}

Dinh-Toi Chu ^{[60
]}

Costa, Vera M. ^{[52
,53
]}

Darwish, Amira Hamed ^{[43
,62
]}

Demeke, Feleke Mekonnen ^{[44
,47
]}

Demis, Asmamaw Bizuneh ^{[63
,64
]}

Demoz, Gebre Teklemariam ^{[65
,67
]}

Dharmaratne, Samath Dhamminda ^{[16
,68
]}

Huyen Phuc Do ^{[70
]}

Linh Phuong Doan ^{[49
,69
]}

Dubey, Manisha ^{[71
]}

Eftekhari, Aziz ^{[12
,72
]}

El-Khatib, Ziad ^{[74
]}

Emamian, Mohammad Hassan ^{[75
]}

Farhangi, Mahdieh Abbasalizad ^{[13
]}

Fernandes, Eduarda ^{[53
]}

Fischer, Florian ^{[76
]}

Fard, Reza Fouladi ^{[77
,78
]}

Friedrich, Paola M. ^{[1
,2
]}

Fukumoto, Takeshi ^{[79
,80
]}

Gedefaw, Getnet Azeze ^{[47
,82
]}

Ghashghaee, Ahmad ^{[24
]}

Gholamian, Asadollah ^{[25
,83
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Global Pediat Med, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] Arak Univ Med Sci, Dept Epidemiol, Arak, Iran

[5] Arak Univ Med Sci, Hlth Serv Management Dept, Arak, Iran

[6] Arak Univ Med Sci, Dept Pediat, Arak, Iran

[7] Multiple Sclerosis Res Ctr, Tehran, Iran

[8] NIH, Social Behav Res Branch, Bldg 10, Bethesda, MD 20892 USA

[9] NHGRI, NIH, Bethesda, MD 20892 USA

[10] Georgetown Univ, Canc Prevent & Control, Washington, DC USA

[11] Directorate Hlth Informat & Res, Dept Hlth, Pieta, Malta

[12] Tabriz Univ Med Sci, Dept Pharmacol & Toxicol, Tabriz, Iran

[13] Tabriz Univ Med Sci, Dept Community Nutr, Tabriz, Iran

[14] Baku State Univ, Baku, Azerbaijan

[15] Mayo Clin, Fdn Med Educ & Res, Evidence Based Practice Ctr, Rochester, MN USA

[16] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA

[17] Univ Washington, Dept Hlth Metr Sci, Seattle, WA 98195 USA

[18] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA

[19] Univ Washington, Div Plast Surg, Seattle, WA 98195 USA

[20] Univ Washington, Dept Surg, Seattle, WA 98195 USA

[21] Univ Washington, Div Hematol, Seattle, WA 98195 USA

[22] Debre Markos Univ, Dept Nursing, Debre Markos, Ethiopia

[23] Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran

[24] Iran Univ Med Sci, Sch Hlth Management & Informat Sci, Dept Hlth Serv Management, Tehran, Iran

[25] Iran Univ Med Sci, Physiol Dept, Tehran, Iran

[26] Iran Univ Med Sci, Dept Plast Surg, Tehran, Iran

[27] Iran Univ Med Sci, Dept Ophthalmol, Tehran, Iran

[28] Iran Univ Med Sci, Dept Hlth Policy, Tehran, Iran

[29] Iran Univ Med Sci, Hlth Promot Res Ctr, Tehran, Iran

[30] Univ Calif Davis, Dept Pediat, Sacramento, CA 95817 USA

[31] Komfo Anokye Teaching Hosp, Dept Internal Med, Kumasi, Ghana

[32] Mansoura Univ, Fac Med, Mansoura, Egypt

[33] Univ Manitoba, Dept Community Hlth Sci, Winnipeg, MB, Canada

[34] Univ Manitoba, Dept Ophthalmol, Winnipeg, MB, Canada

[35] Univ Lahore, Univ Inst Publ Hlth, Lahore, Pakistan

[36] Univ Hail, Publ Hlth Dept, Hail, Saudi Arabia

[37] Indian Inst Publ Hlth, Gandhinagar, India

[38] Publ Hlth Fdn India, Gurugram, India

[39] Sharif Univ Technol, Dept Chem, Tehran, Iran

[40] Univ Aden, Aden, Yemen

[41] Wolaita Sodo Univ, Coll Hlth Sci & Med, Sodo, Ethiopia

[42] Babol Univ Med Sci, Social Determinants Hlth Res Ctr, Babol Sar, Iran

[43] Babol Univ Med Sci, Dept Clin Biochem, Babol Sar, Iran

[44] Dept Med Lab Sci, Bahir Dar, Ethiopia

[45] Dept Neonatal & Pediat Hlth Nursing, Bahir Dar, Ethiopia

[46] Dept Epidemiol & Biostat, Bahir Dar, Ethiopia

[47] Bahir Dar Univ, Bahir Dar, Ethiopia

[48] Imperial Coll London, Who Collaborating Ctr Publ Hlth Educ & Training, London, England

[49] NCD Prevent & Control Unit, Zagreb, Croatia

[50] Minist Hlth, Zagreb, Croatia

来源：

LANCET ONCOLOGY | 2019年 / 20卷 / 09期

基金：

美国国家卫生研究院;

关键词：

SEX-SPECIFIC MORTALITY; SYSTEMATIC ANALYSIS; 195; COUNTRIES; LIFE EXPECTANCY; TERRITORIES; DISABILITY; REGISTRIES; SURVIVAL; INJURIES;

D O I：

10.1016/S1470-2045(19)30339-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). Methods Using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0-19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final point estimates are reported with 95% uncertainty intervals. Findings Globally, in 2017, there were 11.5 million (95% uncertainty interval 10.6-12.3) DALYs due to childhood cancer, 97.3% (97.3-97.3) of which were attributable to YLLs and 2.7% (2.7-2.7) of which were attributable to YLDs. Childhood cancer was the sixth leading cause of total cancer burden globally and the ninth leading cause of childhood disease burden globally. 82.2% (82.1-82.2) of global childhood cancer DALYs occurred in low, low-middle, or middle Socio-demographic Index locations, whereas 50.3% (50.3-50.3) of adult cancer DALYs occurred in these same locations. Cancers that are uncategorised in the current GBD framework comprised 26.5% (26.5-26.5) of global childhood cancer DALYs. Interpretation The GBD 2017 results call attention to the substantial burden of childhood cancer globally, which disproportionately affects populations in resource-limited settings. The use of DALY-based estimates is crucial in demonstrating that childhood cancer burden represents an important global cancer and child health concern. (C) 2019 The Author(s). Published by Elsevier Ltd.

引用

页码：1211 / 1225

页数：15

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