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Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients
被引:8
|作者:
Ambroziak, Urszula
[1
]
Kurylowicz, Alina
[1
]
Kepczynska-Nyk, Anna
[1
]
Bartoszewicz, Zbigniew
[1
]
Kondracka, Agnieszka
[1
]
Jazwiec, Radoslaw
[2
]
Samborowska, Emilia
[2
]
Dadlez, Michal
[2
]
Wyslouch-Cieszynska, Aleksandra
[2
]
Bednarczuk, Tomasz
[1
]
机构:
[1] Med Univ Warsaw, Dept Internal Med & Endocrinol, Banacha St 1a, PL-02097 Warsaw, Poland
[2] Polish Acad Sci, Inst Biochem & Biophys, Mass Spectrometry Lab, Warsaw, Poland
关键词:
testosterone;
dihydrotestosterone;
liquid chromatography/mass spectrometry;
polycystic ovary syndrome;
hyperandrogenism;
POLYCYSTIC-OVARY-SYNDROME;
OBESE WOMEN;
PHENOTYPES;
COHORT;
D O I:
10.5603/GP.a2017.0001
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Objectives: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. Material and methods: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism. In all participants, anthropometric data, lipids, adipose tissue percent (%fat), HOMA-IR were also assessed. Results: The studied groups were not different in terms of age, BMI, waist circumference, %fat and HOMA-IR. In the patients group, mean TT and androstendione levels were significantly higher as compared to controls (1.4 nmol/L vs. 1.0 nmol/L, P < 0.001) and (6.6 nmol/L vs. 4.9 nmol/L, P < 0.01), respectively. In the patients group, mean TT/DHT ratio was significantly higher compared to controls (3.6 vs. 2.7, P < 0.01) and correlated with BMI (r = 0.37, P < 0.05), waist circumference (r = 0.44, P < 0.01), % fat (r = 0.30, P < 0.05), as well as with insulin levels (r = 0.38, P < 0.05) and HOMA-IR (r = 0.44, P < 0.05). The association between TT/DHT ratio and unfavorable metabolic parameters was also seen in controls. Conclusion: Total testosterone/dihydrotestosterone ratio assessed by LC-MS/MS correlates with a worse metabolic profile not only in PCOS patients, but also in healthy women.
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页码:5 / 8
页数:4
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