Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients

被引:8
|
作者
Ambroziak, Urszula [1 ]
Kurylowicz, Alina [1 ]
Kepczynska-Nyk, Anna [1 ]
Bartoszewicz, Zbigniew [1 ]
Kondracka, Agnieszka [1 ]
Jazwiec, Radoslaw [2 ]
Samborowska, Emilia [2 ]
Dadlez, Michal [2 ]
Wyslouch-Cieszynska, Aleksandra [2 ]
Bednarczuk, Tomasz [1 ]
机构
[1] Med Univ Warsaw, Dept Internal Med & Endocrinol, Banacha St 1a, PL-02097 Warsaw, Poland
[2] Polish Acad Sci, Inst Biochem & Biophys, Mass Spectrometry Lab, Warsaw, Poland
关键词
testosterone; dihydrotestosterone; liquid chromatography/mass spectrometry; polycystic ovary syndrome; hyperandrogenism; POLYCYSTIC-OVARY-SYNDROME; OBESE WOMEN; PHENOTYPES; COHORT;
D O I
10.5603/GP.a2017.0001
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. Material and methods: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism. In all participants, anthropometric data, lipids, adipose tissue percent (%fat), HOMA-IR were also assessed. Results: The studied groups were not different in terms of age, BMI, waist circumference, %fat and HOMA-IR. In the patients group, mean TT and androstendione levels were significantly higher as compared to controls (1.4 nmol/L vs. 1.0 nmol/L, P < 0.001) and (6.6 nmol/L vs. 4.9 nmol/L, P < 0.01), respectively. In the patients group, mean TT/DHT ratio was significantly higher compared to controls (3.6 vs. 2.7, P < 0.01) and correlated with BMI (r = 0.37, P < 0.05), waist circumference (r = 0.44, P < 0.01), % fat (r = 0.30, P < 0.05), as well as with insulin levels (r = 0.38, P < 0.05) and HOMA-IR (r = 0.44, P < 0.05). The association between TT/DHT ratio and unfavorable metabolic parameters was also seen in controls. Conclusion: Total testosterone/dihydrotestosterone ratio assessed by LC-MS/MS correlates with a worse metabolic profile not only in PCOS patients, but also in healthy women.
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页码:5 / 8
页数:4
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