Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris

被引:39
作者
Billamboz, Muriel [1 ,2 ]
Fatima, Zeeshan [3 ]
Hameed, Saif [3 ]
Jawhara, Samir [4 ]
机构
[1] Univ Lille, Inst Pasteur Lille, U1167 RID AGE Facteurs Risque & Determinants Mol, CHU Lille,Inserm, F-59000 Lille, France
[2] Lab Sustainable Chem & Hlth, Junia Hlth & Environm, F-59000 Lille, France
[3] Amity Univ Haryana, Amity Inst Biotechnol, Manesar 122413, Gurugram, India
[4] Univ Lille, Ctr Natl Rech Sci, UMR UGSF Unite Glycobiol Struct & Fonct 8576, INSERM U1285, F-59000 Lille, France
关键词
Candida auris; antifungal drugs; repurposed drugs; combinatorial therapy; natural compounds; nanoparticles; DEMONSTRATES IN-VITRO; FUNGAL PATHOGEN; SYNERGISTIC INTERACTIONS; ANTIFUNGAL ACTIVITIES; NOSOCOMIAL FUNGEMIA; BIOFILM FORMATION; SMALL-MOLECULE; CLONAL STRAIN; VIVO ACTIVITY; OPAQUE-PHASE;
D O I
10.3390/microorganisms9030634
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.
引用
收藏
页码:1 / 39
页数:40
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