A simple and efficient synthesis of 2-methyl-2-trifluoromethylchroman-4-ones from 2-trifluoromethyl-4H-chromen-4-imines and malonic acid

被引：8

作者：

Sosnovskikh, VY ^{[1
]}

Usachev, BI ^{[1
]}

机构：

[1] Ural State Univ, Dept Chem, Ekaterinburg 620083, Russia

来源：

SYNTHESIS-STUTTGART | 2002年 / 16期

关键词：

N-benzyl-2-trifluoromethyl-4H-chromen-4-imines; malonic acid; 2-methyl-2-trifluoromethylchroman-4-ones; oxidation; fluorinated analogues of natural compounds;

D O I：

10.1055/s-2002-35233

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzyl-2-trifluoromethyl-4H-chromen-4-imines and malonic acid on heating in anhydrous dioxane afford 2-trifluoromethyl-2-methylchroman-4-ones in similar to60% yield. 2-Methyl-2-trifluoromethyl-4-oxochromane-6-carbaidehyde and 2-methyl-2-trifluoromethyl-4-oxochromane-6-carboxylic acid, the fluorinated analogues of natural lactarochromal and the corresponding acid, were obtained by the oxidation of 2,6-climethyl-2-trifluoromethylchroman-4-one with K2S2O8.

引用

页码：2341 / 2343

页数：3

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