Iridium(III)-Catalyzed C-H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives

被引：5

作者：

Lou, Qin-Xin ^{[1
]}

Li, Jing-Yu ^{[1
]}

Yang, Shang-Dong ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys,Chinese Acad Sci, Lanzhou 730000, Peoples R China

来源：

SYNLETT | 2021年 / 32卷 / 13期

关键词：

triarylphosphine oxides; iridium catalysis; C-H bond activation; aryl dicarbonyl compounds; PALLADIUM-CATALYZED ARYLATION; ASYMMETRIC-SYNTHESIS; ACTIVATION; PHOSPHORUS; AMIDATION; LATAMOXEF; INDOLES; IODIDES; HALIDES; ACCESS;

D O I：

10.1055/a-1409-1906

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel (pentamethylcyclopenta-1,3-dienyl)iridium(III)-catalyzed direct C-H functionalization of triarylphosphine oxides with diazo dicarbonyl compounds through carbene insertion has been developed. This strategy provides a simple and efficient route to the construction of alpha-arylated 1,3-dicarbonyl compounds, which are important building blocks in pharmaceutical chemistry.

引用

页码：1365 / 1370

页数：6

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