Developmental Iodine Deficiency and Hypothyroidism Impair Neural Development, Up-Regulate Caveolin-1 and Down-Regulate Synaptophysin in Rat Hippocampus

被引：29

作者：

Gong, J. ^{[1
]}

Dong, J. ^{[1
]}

Wang, Y. ^{[1
]}

Xu, H. ^{[1
]}

Wei, W. ^{[1
]}

Zhong, J. ^{[1
]}

Liu, W. ^{[1
]}

Xi, Q. ^{[1
,2
]}

Chen, J. ^{[1
]}

机构：

[1] China Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Shenyang 110001, Peoples R China

[2] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Physiol, NL-6525 ED Nijmegen, Netherlands

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2010年 / 22卷 / 02期

关键词：

iodine deficiency; hypothyroidism; hippocampus; Nissl staining; caveolin-1; synaptophysin; THYROID-HORMONE ACTION; AREA CA1; SYNAPTIC-TRANSMISSION; BRAIN-DEVELOPMENT; DENTATE GYRUS; CHOLESTEROL HOMEOSTASIS; ADULT HIPPOCAMPUS; PLASMA-MEMBRANE; BINDING PROTEIN; NERVOUS-SYSTEM;

D O I：

10.1111/j.1365-2826.2009.01943.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Developmental iodine deficiency leads to inadequate thyroid hormone, which damages the hippocampus. In the present study, we implicate hippocampal caveolin-1 and synaptophysin in developmental iodine deficiency and hypothyroidism. Two developmental rat models were established: pregnant rats were administered either an iodine-deficient diet or propylthiouracil (PTU)-adulterated (5 p.p.m. or 15 p.p.m.) drinking water from gestational day 6 until postnatal day (PN) 28. Nissl staining and the levels of caveolin-1 and synaptophysin in several hippocampal subregions were assessed on PN14, PN21, PN28 and PN42. The results obtained show that surviving cells in the iodine-deficient and PTU-treated rats were lower than in controls. Up-regulation of caveolin-1 and down-regulation of synaptophysin were observed in the iodine-deficient and PTU-treated rats. Our findings implicate decreases in the number of surviving cells and alterations in the levels of caveolin-1 and synaptophysin in the impairments in neural development induced by developmental iodine deficiency and hypothyroidism.

引用

页码：129 / 139

页数：11

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