Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes

被引：54

作者：

Brenner, B ^{[1
]}

Koppenhoefer, U ^{[1
]}

Grassme, H ^{[1
]}

Kun, J ^{[1
]}

Lang, F ^{[1
]}

Gulbins, E ^{[1
]}

机构：

[1] UNIV TUBINGEN,DEPT PHYSIOL,D-72076 TUBINGEN,GERMANY

来源：

FEBS LETTERS | 1997年 / 417卷 / 03期

关键词：

CD40; ligand; gp39; T-lymphocytes; tyrosine kinase; Jun-N-terminal kinase;

D O I：

10.1016/S0014-5793(97)01306-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, me provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rad and inhibition of Rad prevents gp39/CD40L triggered JNK/p38-K activation, Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56(lck), Inhibition of src-like kinases inhibits Rad as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56(lck) and Rad to JNK/p38-K. (C) 1997 Federation of European Biochemical Societies.

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收藏

页码：301 / 306

页数：6

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