Molecular biomarkers for lung adenocarcinoma

被引：126

作者：

Calvayrac, Olivier ^{[1
]}

Pradines, Anne ^{[1
,2
,3
,4
]}

Pons, Elvire ^{[1
,3
,4
]}

Mazieres, Julien ^{[1
,2
]}

Guibert, Nicolas ^{[1
,2
]}

机构：

[1] INSERM, Ctr Rech Cancerol Toulouse, CRCT UMR 1037, Toulouse, France

[2] Inst Univ Canc, Toulouse, France

[3] Inst Claudius Regaud, IUCT Oncopole, Lab Biol Med Oncol, Toulouse, France

[4] Univ Paul Sabatier, Hop Larrey, Ctr Hosp Univ, Toulouse, France

来源：

EUROPEAN RESPIRATORY JOURNAL | 2017年 / 49卷 / 04期

关键词：

NONSMALL CELL LUNG; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; PLATINUM-BASED CHEMOTHERAPY; CIRCULATING TUMOR-CELLS; K-RAS MUTATIONS; TRANSBRONCHIAL NEEDLE ASPIRATION; KRAS ONCOGENE SUBSTITUTIONS; HARBORING BRAF MUTATIONS; ALK-GENE REARRANGEMENT;

D O I：

10.1183/13993003.01734-2016

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The identification of oncogenic driver alterations that underlie sensitivity to small inhibitors has led to growing interest in identifying additional targetable oncogenes in nonsmall cell lung cancer. Although the therapeutic impact of the discovery of these alterations has now been widely demonstrated, the epidemiological data associated with each of these biomarkers remain insufficiently studied. In this review, we discuss the techniques used to discover each of these candidate oncogenes, their prevalence in nonsmall cell lung cancer, and briefly outline the epidemiological features of the major oncogenes and ways in which their identification can determine therapeutic strategies.

引用

页数：17

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