Molecular biomarkers for lung adenocarcinoma

被引：121
作者：
Calvayrac, Olivier [1 ]
Pradines, Anne [1 ,2 ,3 ,4 ]
Pons, Elvire [1 ,3 ,4 ]
Mazieres, Julien [1 ,2 ]
Guibert, Nicolas [1 ,2 ]
机构：
[1] INSERM, Ctr Rech Cancerol Toulouse, CRCT UMR 1037, Toulouse, France
[2] Inst Univ Canc, Toulouse, France
[3] Inst Claudius Regaud, IUCT Oncopole, Lab Biol Med Oncol, Toulouse, France
[4] Univ Paul Sabatier, Hop Larrey, Ctr Hosp Univ, Toulouse, France
来源：
EUROPEAN RESPIRATORY JOURNAL | 2017年 / 49卷 / 04期
关键词：
NONSMALL CELL LUNG; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; PLATINUM-BASED CHEMOTHERAPY; CIRCULATING TUMOR-CELLS; K-RAS MUTATIONS; TRANSBRONCHIAL NEEDLE ASPIRATION; KRAS ONCOGENE SUBSTITUTIONS; HARBORING BRAF MUTATIONS; ALK-GENE REARRANGEMENT;
D O I：
10.1183/13993003.01734-2016
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The identification of oncogenic driver alterations that underlie sensitivity to small inhibitors has led to growing interest in identifying additional targetable oncogenes in nonsmall cell lung cancer. Although the therapeutic impact of the discovery of these alterations has now been widely demonstrated, the epidemiological data associated with each of these biomarkers remain insufficiently studied. In this review, we discuss the techniques used to discover each of these candidate oncogenes, their prevalence in nonsmall cell lung cancer, and briefly outline the epidemiological features of the major oncogenes and ways in which their identification can determine therapeutic strategies.
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页数：17
相关论文
共 176 条
  • [1] Ahrendt SA, 2001, CANCER, V92, P1525, DOI 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO
  • [2] 2-H
  • [3] Multiplexed Molecular Profiling of Lung Cancer Using Pleural Effusion
    Akamatsu, Hiroaki
    Koh, Yasuhiro
    Kenmotsu, Hirotsugu
    Naito, Tateaki
    Serizawa, Masakuni
    Kimura, Madoka
    Mori, Keita
    Imai, Hisao
    Ono, Akira
    Shukuya, Takehito
    Taira, Tetsuhiko
    Murakami, Haruyasu
    Ohde, Yasuhisa
    Endo, Masahiro
    Nakajima, Takashi
    Takahashi, Toshiaki
    Yamamoto, Nobuyuki
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (07) : 1048 - 1052
  • [4] Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway
    Andrew, SD
    Capes-Davis, A
    Delhanty, PJD
    Marsh, DJ
    Mulligan, LM
    Robinson, BG
    [J]. GENE, 2002, 298 (01) : 9 - 19
  • [5] Prevalence, Clinicopathologic Associations, and Molecular Spectrum of ERBB2 (HER2) Tyrosine Kinase Mutations in Lung Adenocarcinomas
    Arcila, Maria E.
    Chaft, Jamie E.
    Nafa, Khedoudja
    Roy-Chowdhuri, Sinchita
    Lau, Christopher
    Zaidinski, Michael
    Paik, Paul K.
    Zakowski, Maureen F.
    Kris, Mark G.
    Ladanyi, Marc
    [J]. CLINICAL CANCER RESEARCH, 2012, 18 (18) : 4910 - 4918
  • [6] The impact of common and rare EGFR mutations in response to EGFR tyrosine kinase inhibitors and platinum-based chemotherapy in patients with non-small cell lung cancer
    Arrieta, Oscar
    Felipe Cardona, Andres
    Corrales, Luis
    Delia Campos-Parra, Alma
    Sanchez-Reyes, Roberto
    Amieva-Rivera, Eduardo
    Rodriguez, July
    Vargas, Carlos
    Carranza, Hernan
    Otero, Jorge
    Karachaliou, Nikki
    Astudillo, Horacio
    Rosell, Rafael
    [J]. LUNG CANCER, 2015, 87 (02) : 169 - 175
  • [7] Genotyping Non-small Cell Lung Cancer (NSCLC) in Latin America
    Arrieta, Oscar
    Felipe Cardona, Andres
    Federico Bramuglia, Guillermo
    Gallo, Aly
    Campos-Parra, Alma D.
    Serrano, Silvia
    Castro, Marcelo
    Aviles, Alejandro
    Amorin, Edgar
    Kirchuk, Ricardo
    Cuello, Mauricio
    Borbolla, Jose
    Riemersma, Omar
    Becerra, Henry
    Rosell, Rafael
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (11) : 1955 - 1959
  • [8] Virtual Bronchoscopic Navigation for Peripheral Pulmonary Lesions
    Asano, Fumihiro
    Eberhardt, Ralf
    Herth, Felix J. F.
    [J]. RESPIRATION, 2014, 88 (05) : 430 - 440
  • [9] MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression
    Awad, Mark M.
    Oxnard, Geoffrey R.
    Jackman, David M.
    Savukoski, Daniel O.
    Hall, Dimity
    Shivdasani, Priyanka
    Heng, Jennifer C.
    Dahlberg, Suzanne E.
    Anne, Pasi A. J.
    Verma, Suman
    Christensen, James
    Hammerman, Peter S.
    Sholl, Lynette M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (07) : 721 - +
  • [10] Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
    Barlesi, Fabrice
    Mazieres, Julien
    Merlio, Jean-Philippe
    Debieuvre, Didier
    Mosser, Jean
    Lena, Herve
    Ouafik, L'Houcine
    Besse, Benjamin
    Rouquette, Isabelle
    Westeel, Virginie
    Escande, Fabienne
    Monnet, Isabelle
    Lemoine, Antoinette
    Veillon, Remi
    Blons, Helene
    Audigier-Valette, Clarisse
    Bringuier, Pierre-Paul
    Lamy, Regine
    Beau-Faller, Michele
    Pujol, Jean-Louis
    Sabourin, Jean-Christophe
    Penault-Llorca, Frederique
    Denis, Marc G.
    Lantuejoul, Sylvie
    Morin, Franck
    Quan Tran
    Missy, Pascale
    Langlais, Alexandra
    Milleron, Bernard
    Cadranel, Jacques
    Soria, Jean-Charles
    Zalcman, Gerard
    [J]. LANCET, 2016, 387 (10026) : 1415 - 1426
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