N-methylation of quinolines with CO2 and H2 catalyzed by Ru-triphos complexes

被引：26

作者：

He, Zhenhong ^{[1
,3
]}

Liu, Huizhen ^{[1
,2
]}

Qian, Qingli ^{[1
]}

Lu, Lu ^{[1
]}

Guo, Weiwei ^{[1
]}

Zhang, Lujun ^{[1
]}

Han, Buxing ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface & Thermodynam, Inst Chem, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Xian 710021, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2017年 / 60卷 / 07期

基金：

中国国家自然科学基金;

关键词：

methylation; hydrogenation; quinoline derivatives; carbon dioxide; homogeneous catalysis; SUPPORTED GOLD CATALYSTS; MILD REACTION CONDITIONS; CARBON-DIOXIDE; MOLECULAR-HYDROGEN; TETRAHYDROQUINOLINE ALKALOIDS; ASYMMETRIC-SYNTHESIS; ALLYLIC AMINATION; CARBOXYLIC-ACIDS; SECONDARY-AMINES; ANGUSTUREINE;

D O I：

10.1007/s11426-017-9024-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-methyl-tetrahydroquinolines (MTHQs) are a kind of very useful chemicals, which can be obtained from N-methylation of amines. However, the methylation of quinolines which is a kind of highly unsaturated nitrogen-containing heterocyclic aromatic compounds has not been reported. In this work, we report the first work for the synthesis of MTHQs by methylation of quinolines using CO2 and H-2. It was found that Ru(acac)(3)-triphos [triphos: 1,1,1-tris(diphenylphosphinomethyl)ethanl] complex was very active and selective for the N-methylation reaction of quinolines, and the yield of the desired product could reach 99%.

引用

页码：927 / 933

页数：7

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