Synthesis of 2, 4-Disubstituted Quinazolines via One-Pot Three-Component Assembly

被引：3
|
作者：
Dasaradhan, Changalaraya [1 ,2 ]
Nawaz Khan, Fazlur-Rahman [1 ]
机构：
[1] VIT Univ, Sch Adv Sci, Organ Chem Div, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India
[2] Global Calcium Pvt Ltd, Global Innovat Ctr Subsidiary, Hosur 635126, Tamil Nadu, India
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 06期
关键词：
24-disubstituted quinazolines; quinoline containing quinazolines; urea; ammonium acetate; ANTIINFLAMMATORY EVALUATION; ORGANIC-REACTIONS; DERIVATIVES; 2-PHENYLQUINAZOLINES; DOCKING;
D O I：
10.1080/10406638.2021.1876112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Catalyst free efficient and straightforward method is accounted for the synthesis of 2,4-disubstituted quinazolines utilizing urea was seen as a modest, nontoxic, easily biodegradable, and powerful reaction medium. This productive and straight forward method furnished the corresponding 2,4-disubstituted quinazolines in significant yields employing a one-pot three-component reaction of 2-amino benzophenones, aldehyde, and urea under aerobic oxidation conditions. Additionally, 2-methyl-4-phenylquinazolines were synthesized using ammonium acetate with readily available 2-amino benzophenones.
引用
收藏
页码：3821 / 3828
页数：8
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