Determination of doxycycline in pharmaceuticals and human urine by micellar electrokinetic capillary chromatography

被引：26

作者：

Injac, Rade ^{[1
]}

Kac, Javor ^{[1
]}

Kreft, Samo ^{[1
]}

Strukelj, Borut ^{[1
]}

机构：

[1] Univ Ljubljana, Inst Pharmaceut Biol, Fac Pharm, Ljubljana 1000, Slovenia

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2007年 / 387卷 / 02期

关键词：

doxycycline; micellar electrokinetic capillary chromatography (MEKC); pharmaceuticals; human urine;

D O I：

10.1007/s00216-006-0900-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Micellar electrokinetic capillary chromatography (MEKC) was performed at 25 degrees C and 30 kV (under a pressure of 15 mbar), using 30 mM borate buffer containing 60 mM sodium dodecysulfate (SDS) and 5% (v/v) methanol as background electrolyte (pH 9.0) to determine doxycycline. UV detection was at 350 nm. The method was shown to be specific, accurate (recovery was 100.3 +/- 1.0%), linear over the tested range (correlation coefficient 0.9995) and precise (RSD < 1.9%). The method was used to determine doxycycline in tablets, capsules and human urine after oral application.

引用

页码：695 / 701

页数：7

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