5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition

被引：372

作者：

Sethy, Chinmayee ^{[1
]}

Kundu, Chanakya Nath ^{[1
]}

机构：

[1] Kalinga Inst Ind Technol, Sch Biotechnol, Canc Biol Div, Campus 11, Bhubaneswar 751024, Odisha, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 137卷

关键词：

5-FU resistance; Cancer stemness; Angiogenesis; DNA repair; MDR modulators; Combination therapy; BASE EXCISION-REPAIR; B RECEPTOR PROMOTES; COLORECTAL-CANCER; COLON-CANCER; GASTRIC-CANCER; THYMIDYLATE SYNTHASE; TARGETED DELIVERY; HOMOLOGOUS RECOMBINATION; MESENCHYMAL TRANSITION; GENE POLYMORPHISMS;

D O I：

10.1016/j.biopha.2021.111285

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

5-Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the knowledge of its mechanism of action, various treatment modalities have been developed over the past few decades to increase its anti-cancer activity. But drug resistance has greatly affected the clinical use of 5-FU. Overcoming this chemoresistance is a challenge due to the presence of cancer stem cells like cells, cancer recurrence, metastasis, and angiogenesis. In this review, we have systematically discussed the mechanism of 5-FU resistance and advent strategies to increase the sensitivity of 5-FU therapy including resistance reversal. Special emphasis has been given to the cancer stem cells (CSCs) mediated 5-FU chemoresistance and its reversal process by different approaches including the DNA repair inhibition process.

引用

页数：15

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