Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model

被引：14

作者：

Suzuki, M ^{[1
]}

Sasamata, M ^{[1
]}

Miyata, K ^{[1
]}

机构：

[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Pharmacol Labs, Tsukuba, Ibaraki 3058585, Japan

来源：

BRAIN RESEARCH | 2003年 / 959卷 / 01期

关键词：

AMPA receptor; YM872; tissue-type plasminogen activator (t-PA); coadministration; embolic stroke model;

D O I：

10.1016/S0006-8993(02)03759-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

YM872, an AMPA receptor antagonist, was administered together with t-PA to investigate the effects of coadministration on neuroprotection in a rat embolic stroke model, when administered 2 h after embolism. T-PA or YM872 alone decreased infarct volume and improved the neurological deficit score. Coadministration of YM872 and t-PA resulted in a further decrease in infarct volume and improvement of the neurological score as compared with single administration of t-PA. These data demonstrate that coadministration of YM872 and t-PA produces more potent neuroprotective effects than when t-PA is administered alone. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：169 / 172

页数：4

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