Solubility study of ketoconazole in the mixtures of N-methyl-2-pyrrolidone and ethanol at different temperatures

被引：4

作者：

Moradi, Milad ^{[1
,2
,3
]}

Rahimpour, Elaheh ^{[2
,3
,4
]}

Zhao, Hongkun ^{[5
]}

Martinez, Fleming ^{[6
]}

Jouyban, Abolghasem ^{[2
,3
,7
]}

机构：

[1] Tabriz Univ Med Sci, Student Res Comm Fac Pharm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran

[5] YangZhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[6] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fis Quim,Sede Bogota, Cra 30 45-03, Bogota, DC, Colombia

[7] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 326卷

关键词：

Solubility; Ketoconazole; N-Methyl-2-pyrrolidone; Cosolvency models; Dissolution thermodynamics;

D O I：

10.1016/j.molliq.2021.115287

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility profile of ketoconazole (KTZ) in the binary mixtures of N-methyl-2-pyrrolidone and ethanol is determined by a shake-flask method followed by a spectrophotometry method in the temperature range of 293.2-313.2 K. The obtained solubility values of KTZ are correlated using some linear and non-linear cosolvency models. Moreover, the density of saturated mixtures is also represented by the Jouyban-Acree model at different temperatures. The accuracy of each used model is investigated by the mean relative deviations (MRD %) of the back-calculated solubility and density data. The apparent thermodynamic properties of KTZ dissolution are also computed based on the van't Hoff and Gibbs equations. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：6

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