Extracellular vesicles in immunomodulation and tumor progression

被引：397

作者：

Marar, Carolyn ^{[1
,2
,7
]}

Starich, Bartholomew ^{[1
,3
]}

Wirtz, Denis ^{[1
,3
,4
,5
,6
]}

机构：

[1] Johns Hopkins Univ, Inst NanoBiotechnol INBT, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[3] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Dept Oncol, Sidney Kimmel Canc Ctr, Sch Med, Baltimore, MD 21218 USA

[5] Johns Hopkins Univ, Dept Pathol, Sidney Kimmel Canc Ctr, Sch Med, Baltimore, MD 21218 USA

[6] Johns Hopkins Univ, Johns Hopkins Phys Sci Oncol Ctr, Baltimore, MD 21218 USA

[7] Boston Univ, Biomed Engn Dept, Boston, MA USA

来源：

NATURE IMMUNOLOGY | 2021年 / 22卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CELL-DERIVED EXOSOMES; NATURAL-KILLER-CELLS; DENDRITIC CELLS; T-CELLS; ANTIGEN PRESENTATION; MEMBRANE-VESICLES; DEPENDENT PATHWAY; LUNG-CANCER; FAS LIGAND; STIMULATION;

D O I：

10.1038/s41590-021-00899-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extracellular vesicles have emerged as prominent regulators of the immune response during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a critical role in immunomodulation. Here, we identify the role of EVs as mediators of communication between cancer and immune cells. This expanded role of EVs may shed light on the mechanisms behind tumor progression and provide translational diagnostic and prognostic tools for immunologists. Extracellular vesicles (EVs) can exert potent immunomodulatory effects. Wirtz and colleagues review the types of EV and their influence on tumor responses.

引用

页码：560 / 570

页数：11

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