Potentiometric Determination of pKa Values of Some Quinolones in Methanol-water and Acetonitrile-water Binary Mixtures

被引：0
作者：
Sardohan, Tugba [1 ]
Kir, Esengul [1 ]
机构：
[1] Suleyman Demirel Univ, Fac Sci & Art, Dept Chem, TR-32260 Isparta, Turkey
来源：
CHEMIA ANALITYCZNA | 2009年 / 54卷 / 04期
关键词：
Dissociation constants; Quinolones; Potentiometry; Methanol-water; Acetonitrile-water; CAPILLARY-ZONE-ELECTROPHORESIS; PK(A) VALUES; DISSOCIATION-CONSTANTS; PREFERENTIAL SOLVATION; HYDROORGANIC MIXTURES; ACIDITY CONSTANTS; PH VALUES; LC; DRUGS;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
pKa values of three quinolone compounds (ciprofloxacin. norfloxacin and enoxacin) in methanol-water (MeOH-water) and acetonitrile-water (ACN-water) mixtures were determined in potentiometric measurements Standardization of the electrode system in MeOH-water and ACN-water mixtures was carried out potentiometrically by Gran's method The obtained results were compared to the literature pKa values determined by various techniques and to the values predicted by the SPARC on-line pK(a) calculator
引用
收藏
页码：629 / 642
页数：14
相关论文
共 19 条
  • [1] A comparative study of capillary zone electrophoresis and pH-potentiometry for determination of dissociation constants
    Andrasi, Melinda
    Buglyo, Peter
    Zekany, Laszlo
    Gaspar, Attila
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 44 (05) : 1040 - 1047
  • [2] PH-metric log P 11.: pKa determination of water-insoluble drugs in organic solvent-water mixtures
    Avdeef, A
    Box, KJ
    Comer, JEA
    Gilges, M
    Hadley, M
    Hibbert, C
    Patterson, W
    Tam, KY
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 20 (04) : 631 - 641
  • [3] Dissociation constants and preferential solvation of fluoroquinolones in hydroorganic mixtures used in LC
    Barbosa, J
    Berges, R
    Toro, I
    SanzNebot, V
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 149 (02) : 213 - 225
  • [4] Protonation equilibria of quinolone antibacterials in acetonitrile-water mobile phases used in LC
    Barbosa, J
    Berges, R
    Toro, I
    SanzNebot, V
    [J]. TALANTA, 1997, 44 (07) : 1271 - 1283
  • [5] Evaluation of electrophoretic method versus chromatographic, potentiometric and absorptiometric methodologies for determing pKa values of quinolones in hydroorganic mixtures
    Barbosa, J
    Barrón, D
    Cano, J
    Jiménez-Lozano, E
    Sanz-Nebot, V
    Toro, I
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 24 (5-6) : 1087 - 1098
  • [6] Comparison between capillary electrophoresis, liquid chromatography, potentiometric and spectrophotometric techniques for evaluation of pKa values of zwitterionic drugs in acetonitrile-water mixtures
    Barbosa, J
    Barrón, D
    Jiménez-Lozano, E
    Sanz-Nebot, V
    [J]. ANALYTICA CHIMICA ACTA, 2001, 437 (02) : 309 - 321
  • [7] Spectrophotometric, potentiometric and chromatographic pKa values of polyphenolic acids in water and acetonitrile-water media
    Beltrán, JL
    Sanli, N
    Fonrodona, G
    Barrón, D
    Özkan, G
    Barbosa, J
    [J]. ANALYTICA CHIMICA ACTA, 2003, 484 (02) : 253 - 264
  • [8] VARIATION OF ACIDITY CONSTANTS AND PH VALUES OF SOME ORGANIC-ACIDS IN WATER-2-PROPANOL MIXTURES WITH SOLVENT COMPOSITION - EFFECT OF PREFERENTIAL SOLVATION
    BOSCH, E
    RAFOLS, C
    ROSES, M
    [J]. ANALYTICA CHIMICA ACTA, 1995, 302 (01) : 109 - 119
  • [9] Retention of ionizable compounds on HPLC. pH scale in methanol-water and the pK and pH values of buffers
    Bosch, E
    Bou, P
    Allemann, H
    Roses, M
    [J]. ANALYTICAL CHEMISTRY, 1996, 68 (20) : 3651 - 3657
  • [10] Determination of pKa values of some hydroxylated benzoic acids in methanol-water binary mixtures by LC methodology and potentiometry
    Erdemgil, F. Z.
    Sanli, S.
    Sanli, N.
    Ozkan, G.
    Barbosa, J.
    Guiteras, J.
    Beltran, J. L.
    [J]. TALANTA, 2007, 72 (02) : 489 - 496
12