Molecular Markers in Thyroid Cancer Diagnostics

被引：47

作者：

Kato, Meredith A. ^{[1
]}

Fahey, Thomas J., III ^{[1
]}

机构：

[1] New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Surg, Div Endocrine Surg, New York, NY 10068 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2009年 / 89卷 / 05期

关键词：

Thyroid cancer diagnostics; Thyroid FNA; Thyroid cancer; Galectin-3; HBME-1; Microarray; FINE-NEEDLE-ASPIRATION; TELOMERASE REVERSE-TRANSCRIPTASE; PAX8-PPAR-GAMMA FUSION ONCOGENE; RELIABLY DISTINGUISH BENIGN; HTERT GENE-EXPRESSION; PAPILLARY CARCINOMAS; BRAF(V600E) MUTATION; BRAF MUTATIONS; RET/PTC REARRANGEMENTS; FOLLICULAR NEOPLASMS;

D O I：

10.1016/j.suc.2009.06.012

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Although fine-needle aspiration biopsy (FNA) remains the mainstay of the preoperative workup of thyroid nodules, it does not provide a diagnosis in up to 20% of nodules. This group of indeterminate lesions, including lesions with cellular atypia, suspicious cytology, and demonstrating a follicular pattern, provides one of the greatest challenges to researchers in thyroid cancer today. Over the last 2 decades, considerable work has been done to find molecular markers to resolve this diagnostic dilemma. This article explores some of the markers including galectin-3, HBME-1, BRAF, RET/PTC, PAX8-PPAR gamma, hTERT, telomerase, miRNA, and microarray and multigene assays. Although no one marker has proven to be a panacea, several combinations of markers have shown great promise as an adjunct to FNA.

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收藏

页码：1139 / +

页数：18

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