Stem cells versus plasticity in liver and pancreas regeneration

被引：134

作者：

Kopp, Janel L. ^{[1
]}

Grompe, Markus ^{[2
]}

Sander, Maike ^{[3
]}

机构：

[1] Univ British Columbia, Dept Cellular & Physiol Sci, Vancouver, BC V6T 1Z3, Canada

[2] Oregon Hlth & Sci Univ, Oregon Stem Cell Ctr, Pape Family Pediat Res Inst, Portland, OR 97239 USA

[3] Univ Calif San Diego, Dept Pediat & Cellular & Mol Med, Pediat Diabet Res Ctr, Sanford Consortium Regenerat Med, La Jolla, CA 92093 USA

来源：

NATURE CELL BIOLOGY | 2016年 / 18卷 / 03期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

ADULT-MOUSE PANCREAS; HEPATIC PROGENITOR CELLS; LINEAGE TRACING REVEALS; SELF-DUPLICATION RATHER; IN-VITRO EXPANSION; BETA-CELL; OVAL CELLS; PARTIAL-PANCREATECTOMY; DUCTULAR REACTION; ENDOCRINE-CELLS;

D O I：

10.1038/ncb3309

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.

引用

页码：238 / 245

页数：8

共 144 条

[1] A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver [J].

Akhurst, B ;

Croager, EJ ;

Farley-Roche, CA ;

Ong, JK ;

Dumble, ML ;

Knight, B ;

Yeoh, GC .

HEPATOLOGY, 2001, 34 (03) :519-522

[2]

ARBER N, 1988, LIVER, V8, P80

[3]

Arias I.M., 1994, The Liver: Biology and Pathobiology, VThird

[4] Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].

Barker, Nick ;

van Es, Johan H. ;

Kuipers, Jeroen ;

Kujala, Pekka ;

van den Born, Maaike ;

Cozijnsen, Miranda ;

Haegebarth, Andrea ;

Korving, Jeroen ;

Begthel, Harry ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2007, 449 (7165) :1003-U1

[5] Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration [J].

Barker, Nick .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (01) :19-33

[6] Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].

Barker, Nick ;

Huch, Meritxell ;

Kujala, Pekka ;

van de Wetering, Marc ;

Snippert, Hugo J. ;

van Es, Johan H. ;

Sato, Toshiro ;

Stange, Daniel E. ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

van den Brink, Stieneke ;

Korving, Jeroen ;

Abo, Arie ;

Peters, Peter J. ;

Wright, Nick ;

Poulsom, Richard ;

Clevers, Hans .

CELL STEM CELL, 2010, 6 (01) :25-36

[7] Studies on the pancreas of the guinea pig [J].

Bensley, RR .

AMERICAN JOURNAL OF ANATOMY, 1911, 12 (03) :297-388

[8] Human cirrhosis: Monoclonal regenerative nodules derived from hepatic progenitor cells abutting ductular reaction [J].

Bioulac-Sage, P. ;

Balabaud, C. .

GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 2010, 34 (4-5) :267-269

[9] Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling [J].

Blaine, Stacy A. ;

Ray, Kevin C. ;

Anunobi, Reginald ;

Gannon, Maureen A. ;

Washington, Mary K. ;

Means, Anna L. .

DEVELOPMENT, 2010, 137 (14) :2289-2296

[10] ORIGIN OF TUBULAR COMPLEXES IN HUMAN CHRONIC-PANCREATITIS [J].

BOCKMAN, DE ;

BOYDSTON, WR ;

ANDERSON, MC .

AMERICAN JOURNAL OF SURGERY, 1982, 144 (02) :243-249

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