Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

被引：83

作者：

Kornmann, M

Link, KH

Lenz, HJ

Pillasch, J

Metzger, R

Butzer, U

Leder, GH

Weindel, M

Safi, F

Danenberg, KD

Beger, HG

Danenberg, PV

机构：

[1] UNIV SO CALIF,SCH MED,KENNETH NORRIS JR CANC HOSP & RES INST,DEPT BIOCHEM,LOS ANGELES,CA 90033

[2] UNIV ULM,DEPT GEN SURG,ULM,GERMANY

来源：

CANCER LETTERS | 1997年 / 118卷 / 01期

关键词：

chemosensitivity; chemotherapy; colorectal cancer; hepatic artery infusion; predictive parameter; thymidylate synthase;

D O I：

10.1016/S0304-3835(97)00220-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10(-3) (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：29 / 35

页数：7

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