HIV-1 reverse transcriptase inhibitory principles from Chamaesyce hyssopifolia

被引：0
|
作者：
Lim, YA
Mei, MC
Kusumoto, IT
Miyashiro, H
Hattori, M
Gupta, MP
Correa, M
机构：
[1] RES INST WAKAN YAKU TRADIT SINO JAPANESE MED,TOYAMA 93001,JAPAN
[2] UNIV PANAMA,HERBARIUM,PANAMA CITY,PANAMA
[3] SMITHSONIAN TROP RES INST,BALBOA,PANAMA
[4] UNIV PANAMA,COLL PHARM,PHARMACOGNOSY RES CTR PANAMANIAN FLORA,PANAMA CITY,PANAMA
来源：
PHYTOTHERAPY RESEARCH | 1997年 / 11卷 / 01期
关键词：
Chamaesyce hyssopifolia; HIV; Panamanian plant; reverse transcriptase;
D O I：
10.1002/(SICI)1099-1573(199702)11:1<22::AID-PTR951>3.0.CO;2-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the course of our studies on the development of anti-acquired immunodeficiency syndrome (AIDS) agents, we isolated corilagin, quercetin 3-O-beta-D-glucopyranoside and 1,3,4,6-tetra-O-galloyl-beta-D-glucopyranos from Chamaesyce hyssopifolia, as the main inhibitory substances against human immunodeficiency virus (HIV) reverse transcriptase, an enzyme essential for the proliferation of HIV. The IC50 of these substances were 20, 50 and 86 mu M, respectively, their modes of inhibition being non-competitive with respect to the substrate. (C) 1997 by John Wiley & Sons, Ltd.
引用
收藏
页码：22 / 27
页数：6
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