Nanoscale bio-platforms for living cell interrogation: current status and future perspectives

被引:35
作者
Chang, Lingqian [1 ,3 ]
Hu, Jiaming [1 ]
Chen, Feng [1 ,4 ]
Chen, Zhou [1 ,5 ]
Shi, Junfeng [1 ]
Yang, Zhaogang [1 ]
Li, Yiwen [2 ]
Lee, Ly James [1 ,3 ]
机构
[1] Ohio State Univ, NSF Nanoscale Sci & Engn Ctr NSEC, Columbus, OH 43212 USA
[2] Sichuan Univ, State Key Lab Polymer Mat Engn, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China
[3] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43212 USA
[4] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou, Zhejiang, Peoples R China
[5] Nanjing Univ Aeronaut & Astronaut, Coll Mat Sci & Technol, Nanjing 210016, Jiangsu, Peoples R China
基金
美国国家科学基金会;
关键词
SCANNING ELECTROCHEMICAL MICROSCOPY; FUNCTIONAL PHOTOACOUSTIC MICROSCOPY; FIELD-EFFECT TRANSISTORS; ATOMIC-FORCE MICROSCOPY; HIGH-THROUGHPUT; GENE DELIVERY; HIGH-RESOLUTION; ACTION-POTENTIALS; QUANTUM DOTS; STEM-CELLS;
D O I
10.1039/c5nr06694h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The living cell is a complex entity that dynamically responds to both intracellular and extracellular environments. Extensive efforts have been devoted to the understanding intracellular functions orchestrated with mRNAs and proteins in investigation of the fate of a single-cell, including proliferation, apoptosis, motility, differentiation and mutations. The rapid development of modern cellular analysis techniques (e.g. PCR, western blotting, immunochemistry, etc.) offers new opportunities in quantitative analysis of RNA/protein expression up to a single cell level. The recent entries of nanoscale platforms that include kinds of methodologies with high spatial and temporal resolution have been widely employed to probe the living cells. In this tutorial review paper, we give insight into background introduction and technical innovation of currently reported nanoscale platforms for living cell interrogation. These highlighted technologies are documented in details within four categories, including nano-biosensors for label-free detection of living cells, nanodevices for living cell probing by intracellular marker delivery, high-throughput platforms towards clinical current, and the progress of microscopic imaging platforms for cell/tissue tracking in vitro and in vivo. Perspectives for system improvement were also discussed to solve the limitations remains in current techniques, for the purpose of clinical use in future.
引用
收藏
页码:3181 / 3206
页数:26
相关论文
共 260 条
[11]   Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain [J].
Barbosa, Joana S. ;
Sanchez-Gonzalez, Rosario ;
Di Giaimo, Rossella ;
Baumgart, Emily Violette ;
Theis, Fabian J. ;
Goetz, Magdalena ;
Ninkovic, Jovica .
SCIENCE, 2015, 348 (6236) :789-793
[12]   Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum [J].
Bendall, Sean C. ;
Simonds, Erin F. ;
Qiu, Peng ;
Amir, El-ad D. ;
Krutzik, Peter O. ;
Finck, Rachel ;
Bruggner, Robert V. ;
Melamed, Rachel ;
Trejo, Angelica ;
Ornatsky, Olga I. ;
Balderas, Robert S. ;
Plevritis, Sylvia K. ;
Sachs, Karen ;
Pe'er, Dana ;
Tanner, Scott D. ;
Nolan, Garry P. .
SCIENCE, 2011, 332 (6030) :687-696
[13]   Recent advances in high resolution scanning electrochemical microscopy of living cells - A review [J].
Bergner, Stefan ;
Vatsyayan, Preety ;
Matysik, Frank-Michael .
ANALYTICA CHIMICA ACTA, 2013, 775 :1-13
[14]   Fluid domain patterns in free-standing membranes captured on a solid support [J].
Bhatia, Tripta ;
Husen, Peter ;
Ipsen, John H. ;
Bagatolli, Luis A. ;
Simonsen, Adam Cohen .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2014, 1838 (10) :2503-2510
[15]   Single-cell mass cytometry for analysis of immune system functional states [J].
Bjornson, Zach B. ;
Nolan, Garry P. ;
Fantl, Wendy J. .
CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (04) :484-494
[16]   Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis [J].
Bock, Felix ;
Onderka, Jasmine ;
Dietrich, Tina ;
Bachmann, Bjorn ;
Kruse, Friedrich E. ;
Paschke, Matthias ;
Zahn, Grit ;
Cursiefen, Claus .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (06) :2545-2552
[17]  
Boukany PE, 2011, NAT NANOTECHNOL, V6, P747, DOI [10.1038/NNANO.2011.164, 10.1038/nnano.2011.164]
[18]   The Birth of Optogenetics [J].
Boyden, Edward S. .
SCIENTIST, 2011, 25 (07) :30-35
[19]   Millisecond-timescale, genetically targeted optical control of neural activity [J].
Boyden, ES ;
Zhang, F ;
Bamberg, E ;
Nagel, G ;
Deisseroth, K .
NATURE NEUROSCIENCE, 2005, 8 (09) :1263-1268
[20]   AFM imaging of fenestrated liver sinusoidal endothelial cells [J].
Braet, F. ;
Wisse, E. .
MICRON, 2012, 43 (12) :1252-1258