Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

被引：75

作者：

Ogonowska, Patrycja ^{[1
,4
]}

Gilaberte, Yolanda ^{[2
]}

Baranska-Rybak, Wioletta ^{[3
]}

Nakonieczna, Joanna ^{[1
,4
]}

机构：

[1] Univ Gdansk, Intercollegiate Fac Biotechnol, Lab Mol Diagnost, Gdansk, Poland

[2] Univ Hosp Miguel Servet, Dept Dermatol, Zaragoza, Spain

[3] Med Univ Gdansk, Dept Dermatol Venereol & Allergol, Gdansk, Poland

[4] Med Univ Gdansk, Gdansk, Poland

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 11卷

关键词：

epidemiology of S; aureus; MRSA; staphylococcal enterotoxins; antistaphylococcal photodynamic treatment; virulence factor; SKIN COLONIZATION; DISEASE SEVERITY; ANTIMICROBIAL PEPTIDES; STRATUM-CORNEUM; HIGH PREVALENCE; DOUBLE-BLIND; ECZEMA AREA; CHILDREN; SUPERANTIGENS; FILAGGRIN;

D O I：

10.3389/fmicb.2020.567090

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S. aureus) in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant S. aureus (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of S. aureus accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of S. aureus in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived S. aureus. Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

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页数：19

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