Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation

被引：38

作者：

Hiroi, N

Ito, T

Yamamoto, H

Ochiya, T

Jinno, S

Okayama, H ^{[1
]}

机构：

[1] Univ Tokyo, Dept Biochem & Mol Biol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

[2] Yokohama City Univ, Dept Pathol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[3] Natl Canc Ctr, Sect Studies Metastasis, Chuo Ku, Tokyo 1040045, Japan

来源：

EMBO JOURNAL | 2002年 / 21卷 / 19期

关键词：

development; differentiation; F9; retinoic acid; transcription;

D O I：

10.1093/emboj/cdf521

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucleotide treatment of embryonic mouse lung explants suggests that Rcd1 also plays a role in retinoic acid-controlled lung development.

引用

页码：5235 / 5244

页数：10

共 46 条

[1] Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes [J].