Approach to the Management of Autoimmunity in Primary Immunodeficiency

被引：40

作者：

Azizi, G. ^{[1
,2
]}

Ziaee, V. ^{[3
,4
]}

Tavakol, M. ^{[5
]}

Alinia, T. ^{[2
]}

Yazdai, R. ^{[2
,6
]}

Mohammadi, H. ^{[7
]}

Abolhassani, H. ^{[2
,8
]}

Aghamohammadi, A. ^{[2
]}

机构：

[1] Alborz Univ Med Sci, Imam Hassan Mojtaba Hosp, Dept Lab Med, Karaj, Iran

[2] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Pediat Rheumatol Res Grp, Rheumatol Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Pediat, Tehran, Iran

[5] Alborz Univ Med Sci, Shahid Bahonar Hosp, Dept Allergy & Clin Immunol, Karaj, Iran

[6] Isfahan Univ Med Sci, Dept Immunol, Fac Med, Esfahan, Iran

[7] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran

[8] Karolinska Univ Hosp Huddinge, Karolinska Inst, Div Clin Immunol, Dept Lab Med, Stockholm, Sweden

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2017年 / 85卷 / 01期

关键词：

COMMON VARIABLE IMMUNODEFICIENCY; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CHRONIC GRANULOMATOUS-DISEASE; PRIMARY IMMUNE-DEFICIENCY; JUVENILE IDIOPATHIC ARTHRITIS; PRIMARY ANTIBODY DEFICIENCIES; SELECTIVE IGA DEFICIENCY; REGULATORY T-CELLS; CANDIDIASIS-ECTODERMAL DYSTROPHY; INFLAMMATORY-BOWEL-DISEASE;

D O I：

10.1111/sji.12506

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary immunodeficiency diseases (PIDs) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non-infectious complications, particularly autoimmunity. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and leads to difficulty in the management of autoimmune complications in PID patients. Therefore, management of autoimmunity in patients with PID requires special considerations because dysregulations and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment.

引用

页码：13 / 29

页数：17

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