Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence

被引：44

作者：

Eichhorn, Reinhold ^{[1
]}

Wessler, Gerd ^{[1
]}

Scholz, Matthias ^{[2
]}

Leupold, Dieter ^{[2
]}

Stankovic, Goran ^{[2
]}

Buder, Susanne ^{[3
]}

Stuecker, Markus ^{[4
]}

Hoffmann, Klaus ^{[4
]}

机构：

[1] Praxis Dermatol, D-10711 Berlin, Germany

[2] LTB Lasertech Berlin, D-12489 Berlin, Germany

[3] Vivantes Klinikum Neukolln, Dermatol & Venereol Klin, D-12351 Berlin, Germany

[4] Ruhr Univ Bochum, St Josef Hosp, D-44791 Bochum, Germany

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2009年 / 14卷 / 03期

关键词：

fluorescence of melanocytic nevi; melanoma in situ; two-photon excitation; FEMTOSECOND 2-PHOTON-EXCITED FLUORESCENCE; SPECTROSCOPY;

D O I：

10.1117/1.3155511

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Because of the increasing incidence of skin cancer, interest in using the autofluorescence of skin tissue as a noninvasive tool for early diagnosis is enforced. Focus is especially on malignant melanotic melanoma. On the basis of a newly developed method to selectively excite melanin fluorescence of skin tissue by stepwise two-photon excitation with nanosecond laser pulses at 810 nm, we have investigated information from this melanin fluorescence with respect to the differentiation of pigmented lesions. A distinct difference in the melanin fluorescence spectrum of malignant melanoma (including melanoma in situ) when compared to that of benign melanocytic lesions (i.e., common nevi) has been found for freshly excised samples as well as for histopathological samples. There is also specific fluorescence from dysplastic nevi. In this way, early detection of malignant melanoma is possible. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3155511]

引用

页数：7

共 20 条

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