Autophagy in cancer: Good, bad, or both?

被引：342

作者：

Hippert, Melanie M.

O'Toole, Patrick S.

Thorburn, Andrew

机构：

[1] Univ Colorado Denver & Hlth Sci Ctr, Dept Pharmacol, Aurora, CO 80045 USA

[2] Univ Colorado Denver & Hlth Sci Ctr, Ctr Canc, Aurora, CO 80045 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-06-1597

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy has been recognized as an important cellular process for at least 50 years; however, it is only with the recent identification of key regulators of autophagy (Atg genes) that we have begun a mechanistic exploration of its importance in cancer. Recent studies suggest that autophagy may be important in the regulation of cancer development and progression and in determining the response of tumor cells to anticancer therapy. However, the role of autophagy in these processes is complicated and may, depending on the circumstances, have diametrically opposite consequences for the tumor. In this article, we discuss recent discoveries regarding autophagy in cancer.

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页码：9349 / 9351

页数：3

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