Symptom management: the utility of regional cooling for hand-foot syndrome induced by pegylated liposomal doxorubicin in ovarian cancer

被引：33

作者：

Bun, Seiko ^{[1
]}

Yunokawa, Mayu ^{[2
]}

Tamaki, Yoshiko ^{[1
]}

Shimomura, Akihiko ^{[2
]}

Shimoi, Tatsunori ^{[2
]}

Kodaira, Makoto ^{[2
]}

Shimizu, Chikako ^{[2
]}

Yonemori, Kan ^{[2
]}

Fujiwara, Yasuhiro ^{[2
]}

Makino, Yoshinori ^{[1
]}

Terakado, Hiroyuki ^{[1
]}

Tamura, Kenji ^{[2
]}

机构：

[1] Natl Canc Ctr, Dept Pharm, Tokyo, Japan

[2] Natl Canc Ctr, Dept Breast & Med Oncol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan

来源：

SUPPORTIVE CARE IN CANCER | 2018年 / 26卷 / 07期

关键词：

Pegylated liposomal doxorubicin; Hand-foot syndrome; Frozen gloves and socksmethod; Advanced ovarian cancer; Regional cooling methods; RANDOMIZED PHASE-III; RECURRENT EPITHELIAL OVARIAN; CIRCULATION TIME; FALLOPIAN-TUBE; TRIAL; CARCINOMA; PHARMACOKINETICS; CHEMOTHERAPY; CARBOPLATIN; PACLITAXEL;

D O I：

10.1007/s00520-018-4054-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hand-foot syndrome (HFS) is a major side effect of pegylated liposomal doxorubicin (PLD). Regional cooling during PLD infusion was shown to improve severe HFS. We investigated the utility of frozen gloves and socks (FGS) as a simpler cooling method. To evaluate the utility and safety of regional cooling with FGS for PLD-induced HFS, we retrospectively analyzed patients with advanced ovarian cancer who used FGS during PLD-containing regimens. Ninety-six patients were analyzed. The incidence of HFS was 51% (ae grade 2, 32%) in the PLD group and 38% (ae grade 2, 6%) in the PLD + CBDCA group. The respective percentages of patients who underwent PLD dose modification/discontinuation were 41%/75% in the PLD group and 9%/30% in the PLD + CBDCA group. The reasons for discontinuation of PLD and PLD + CBDCA therapy were progressive disease, HFS, allergy, oral mucositis, and others. HFS was the only reason for PLD dose modification in both the PLD and PLD + CBDCA groups. The completion rate of FGS was 96%, with discontinuation in three cases due to pain from cooling. Our study indicates that FGS is a safe, simple method with good tolerability. A prospective study is needed for further assessment.

引用

页码：2161 / 2166

页数：6

共 16 条

[1] OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer [J].