Stem Cell Therapy for Diabetic Foot Ulcers: Theory and Practice

被引：15

作者：

Nalisa, David Lubasi ^{[1
,2
,3
,4
]}

Moneruzzaman, Md. ^{[5
]}

Changwe, Geoffrey J. ^{[6
]}

Mobet, Youchaou ^{[7
]}

Li, Li Ping ^{[1
,2
,3
,4
]}

Ma, Yu Jin ^{[1
,2
,3
,4
]}

Jiang, Hong Wei ^{[1
,2
,3
,4
]}

机构：

[1] Henan Univ Sci & Technol, Affiliated Hosp 1, Endocrine & Metab Dis Ctr, Dept Metab & Endocrinol, Luoyang 471003, Peoples R China

[2] Henan Univ Sci & Technol, Coll Clin Med, Luoyang 471003, Peoples R China

[3] Med Key Lab Hereditary Rare Dis Henan, Luoyang 471003, Peoples R China

[4] Luoyang Sub Ctr Natl Clin Res Ctr Metab Dis, Luoyang 471003, Peoples R China

[5] Shandong Univ, Qilu Hosp, Dept Rehabil Med & Physiotherapy, Jinan 250012, Shandong, Peoples R China

[6] Natl Heart Hosp, Dept Cardiovasc & Thorac Surg, Off Airport Rd, Lusaka 10101, Zambia

[7] Chongqing Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Chongqing 401120, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2022年 / 2022卷

关键词：

HYPERBARIC-OXYGEN THERAPY; SURGICAL DEBRIDEMENT; LIMB ISCHEMIA; MANAGEMENT; PREVENTION;

D O I：

10.1155/2022/6028743

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic foot ulcers are associated with increases in limb amputation, morbidity, and mortality. Recently, a stem cell application is emerging as promising adjuvant therapy. We presented available remedies by conducting a literature review on the application, safety, and efficacy of stem cell therapy. Relevant literature, including randomized control trials and article journals, was obtained from reputable search engines (PubMed, Scopus, and Web of Science). We analyzed five credible cohorts, with variable sources of stem cells, in a total of 216 participants, 151 males and 65 females, age (mean & PLUSMN;SD) of 64.5 & PLUSMN;9.6 years. With an average success of 86.41% in all Wagner-II lesions, mesenchymal SCA (stem cell application) is safe and effective, hence can significantly prevent limb amputation.

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页数：12

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